Pharmacokinetics of high-dose intravenous ciprofloxacin in young and elderly and in male and female subjects

A. Shah, J. Lettieri, D. Nix, J. Wilton, A. H. Heller

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The effects of age and gender on the pharmacokinetics of high-dose intravenous ciprofloxacin in a healthy volunteer study were investigated. Plasma ciprofloxacin concentrations were higher in the elderly than in the young, and the pharmacokinetic parameters were not significantly different between the genders. Ciprofloxacin was well tolerated, with the majority of adverse events related to local reactions at the IV site.

Original languageEnglish (US)
Pages (from-to)1003-1006
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume39
Issue number4
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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