Pharmacokinetics/Pharmacodynamics of Antiarrhythmic Drugs

Julia H Indik, Raymond L. Woosley

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This article describes the pharmacology of antiarrhythmic medications. Although these medications are broadly considered in terms of their blockade of either sodium or potassium channels, they act by a variety of pharmacodynamic mechanisms. Elimination may be via hepatic metabolism or renal mechanisms, or a combination. In particular, interactions between antiarrhythmic medications and other drugs that interfere with hepatic metabolism by P450 enzymes is a source for toxicity.

Original languageEnglish (US)
Pages (from-to)341-358
Number of pages18
JournalCardiac Electrophysiology Clinics
Volume2
Issue number3
DOIs
StatePublished - Sep 2010

Fingerprint

Anti-Arrhythmia Agents
Pharmacokinetics
Sodium Channels
Liver
Potassium Channels
Cytochrome P-450 Enzyme System
Pharmacology
Kidney
Pharmaceutical Preparations

Keywords

  • Antiarrhythmic medications
  • Drug interactions
  • Pharmacodynamics
  • Pharmacokinetics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Pharmacokinetics/Pharmacodynamics of Antiarrhythmic Drugs. / Indik, Julia H; Woosley, Raymond L.

In: Cardiac Electrophysiology Clinics, Vol. 2, No. 3, 09.2010, p. 341-358.

Research output: Contribution to journalArticle

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