Pharmacokinetics/Pharmacodynamics of Antiarrhythmic Drugs

Julia H. Indik, Raymond L. Woosley

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

This article describes the pharmacology of antiarrhythmic medications. Although these medications are broadly considered in terms of their blockade of either sodium or potassium channels, they act by a variety of pharmacodynamic mechanisms. Elimination may be via hepatic metabolism or renal mechanisms, or a combination. In particular, interactions between antiarrhythmic medications and other drugs that interfere with hepatic metabolism by P450 enzymes is a source for toxicity.

Original languageEnglish (US)
Pages (from-to)341-358
Number of pages18
JournalCardiac Electrophysiology Clinics
Volume2
Issue number3
DOIs
StatePublished - Sep 1 2010

Keywords

  • Antiarrhythmic medications
  • Drug interactions
  • Pharmacodynamics
  • Pharmacokinetics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Pharmacokinetics/Pharmacodynamics of Antiarrhythmic Drugs'. Together they form a unique fingerprint.

Cite this