Pharmacological regulation of blood glucose levels in non-insulin- dependent diabetes mellitus

Rubin Bressler, David G Johnson

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Non-insulin-dependent diabetes mellitus is a metabolic disease that is common and is characterized by insulin insufficiency and resistance. Measures such as body weight reduction and exercise improve the metabolic defects, but pharmacological therapy is the most frequently used and successful therapy. The sulphonylureas stimulate insulin secretion. Metformin and troglitazone increase disposal and decrease hepatic glucose output without causing hypoglycemia. Acarbose is a dietary aid that spreads the dietary carbohydrate challenge to endogenous insulin over time. These pharmacological agents, either alone or in combination, can improve blood glucose regulation in patients with non-insulin-dependent diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)836-848
Number of pages13
JournalArchives of Internal Medicine
Volume157
Issue number8
StatePublished - Apr 28 1997

Fingerprint

troglitazone
Type 2 Diabetes Mellitus
Blood Glucose
Pharmacology
Insulin
Acarbose
Dietary Carbohydrates
Metformin
Metabolic Diseases
Hypoglycemia
Insulin Resistance
Weight Loss
Body Weight
Exercise
Glucose
Liver
Therapeutics

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Pharmacological regulation of blood glucose levels in non-insulin- dependent diabetes mellitus. / Bressler, Rubin; Johnson, David G.

In: Archives of Internal Medicine, Vol. 157, No. 8, 28.04.1997, p. 836-848.

Research output: Contribution to journalArticle

@article{df3ee9f708104f878f457d0e1ef5cae7,
title = "Pharmacological regulation of blood glucose levels in non-insulin- dependent diabetes mellitus",
abstract = "Non-insulin-dependent diabetes mellitus is a metabolic disease that is common and is characterized by insulin insufficiency and resistance. Measures such as body weight reduction and exercise improve the metabolic defects, but pharmacological therapy is the most frequently used and successful therapy. The sulphonylureas stimulate insulin secretion. Metformin and troglitazone increase disposal and decrease hepatic glucose output without causing hypoglycemia. Acarbose is a dietary aid that spreads the dietary carbohydrate challenge to endogenous insulin over time. These pharmacological agents, either alone or in combination, can improve blood glucose regulation in patients with non-insulin-dependent diabetes mellitus.",
author = "Rubin Bressler and Johnson, {David G}",
year = "1997",
month = "4",
day = "28",
language = "English (US)",
volume = "157",
pages = "836--848",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "8",

}

TY - JOUR

T1 - Pharmacological regulation of blood glucose levels in non-insulin- dependent diabetes mellitus

AU - Bressler, Rubin

AU - Johnson, David G

PY - 1997/4/28

Y1 - 1997/4/28

N2 - Non-insulin-dependent diabetes mellitus is a metabolic disease that is common and is characterized by insulin insufficiency and resistance. Measures such as body weight reduction and exercise improve the metabolic defects, but pharmacological therapy is the most frequently used and successful therapy. The sulphonylureas stimulate insulin secretion. Metformin and troglitazone increase disposal and decrease hepatic glucose output without causing hypoglycemia. Acarbose is a dietary aid that spreads the dietary carbohydrate challenge to endogenous insulin over time. These pharmacological agents, either alone or in combination, can improve blood glucose regulation in patients with non-insulin-dependent diabetes mellitus.

AB - Non-insulin-dependent diabetes mellitus is a metabolic disease that is common and is characterized by insulin insufficiency and resistance. Measures such as body weight reduction and exercise improve the metabolic defects, but pharmacological therapy is the most frequently used and successful therapy. The sulphonylureas stimulate insulin secretion. Metformin and troglitazone increase disposal and decrease hepatic glucose output without causing hypoglycemia. Acarbose is a dietary aid that spreads the dietary carbohydrate challenge to endogenous insulin over time. These pharmacological agents, either alone or in combination, can improve blood glucose regulation in patients with non-insulin-dependent diabetes mellitus.

UR - http://www.scopus.com/inward/record.url?scp=0031396662&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031396662&partnerID=8YFLogxK

M3 - Article

C2 - 9129543

AN - SCOPUS:0031396662

VL - 157

SP - 836

EP - 848

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 8

ER -