Phase II evaluation of topotecan in patients with advanced colorectal cancer. A Southwest Oncology Group trial (SWOG 9241)

John S. Macdonald; Jacqueline K. Benedetti; Manuel Modiano; David S. Alberts

doi:10.1023/A:1005941603420

Phase II evaluation of topotecan in patients with advanced colorectal cancer. A Southwest Oncology Group trial (SWOG 9241)

John S. Macdonald, Jacqueline K. Benedetti, Manuel Modiano, David S. Alberts

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The topoisomerase-1 inhibitor, topotecan, was tested in 48 eligible patients with advanced colorectal cancer. The patients had no prior chemotherapy and a Southwest Oncology Group performance status of 0-2. Topotecan was administered intravenously at 1.5 mg/m²/day for five days and repeated every 21 days. The major toxicity was hematologic with 19 out of 48 (40%) patients having grade IV granulocytopenia and 4 out of 48 (8%) patients demonstrating grade IV thrombocytopenia. Two patients (4%) demonstrated partial response. Thirty patients have died and the Kaplan-Meier estimate of median survival is 9 months (95% confidence interval, 7-16 months). Topotecan in this dose and schedule does not appear active in patients with advanced colorectal cancer.

Original language	English (US)
Pages (from-to)	357-359
Number of pages	3
Journal	Investigational New Drugs
Volume	15
Issue number	4
DOIs	https://doi.org/10.1023/A:1005941603420
State	Published - 1997
Externally published	Yes

Keywords

Colorectal cancer
Topoisomerase-1 inhibitor
Topotecan

ASJC Scopus subject areas

Oncology
Pharmacology
Pharmacology (medical)

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10.1023/A:1005941603420

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title = "Phase II evaluation of topotecan in patients with advanced colorectal cancer. A Southwest Oncology Group trial (SWOG 9241)",

abstract = "The topoisomerase-1 inhibitor, topotecan, was tested in 48 eligible patients with advanced colorectal cancer. The patients had no prior chemotherapy and a Southwest Oncology Group performance status of 0-2. Topotecan was administered intravenously at 1.5 mg/m2/day for five days and repeated every 21 days. The major toxicity was hematologic with 19 out of 48 (40%) patients having grade IV granulocytopenia and 4 out of 48 (8%) patients demonstrating grade IV thrombocytopenia. Two patients (4%) demonstrated partial response. Thirty patients have died and the Kaplan-Meier estimate of median survival is 9 months (95% confidence interval, 7-16 months). Topotecan in this dose and schedule does not appear active in patients with advanced colorectal cancer.",

keywords = "Colorectal cancer, Topoisomerase-1 inhibitor, Topotecan",

author = "Macdonald, {John S.} and Benedetti, {Jacqueline K.} and Manuel Modiano and Alberts, {David S.}",

note = "Funding Information: This investigation was supported in part by the following PHS Cooperative Agreement grant numbers awarded by the National Cancer Institute, DHHS: CA 38926, CA32102, CA13612, CA58415, CA46441, CA52772, CA46113, CA35431, CA45461, CA46368, CA35090, Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

year = "1997",

doi = "10.1023/A:1005941603420",

language = "English (US)",

volume = "15",

pages = "357--359",

journal = "Investigational New Drugs",

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AU - Macdonald, John S.

AU - Benedetti, Jacqueline K.

AU - Modiano, Manuel

AU - Alberts, David S.

N1 - Funding Information: This investigation was supported in part by the following PHS Cooperative Agreement grant numbers awarded by the National Cancer Institute, DHHS: CA 38926, CA32102, CA13612, CA58415, CA46441, CA52772, CA46113, CA35431, CA45461, CA46368, CA35090, Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 1997

Y1 - 1997

N2 - The topoisomerase-1 inhibitor, topotecan, was tested in 48 eligible patients with advanced colorectal cancer. The patients had no prior chemotherapy and a Southwest Oncology Group performance status of 0-2. Topotecan was administered intravenously at 1.5 mg/m2/day for five days and repeated every 21 days. The major toxicity was hematologic with 19 out of 48 (40%) patients having grade IV granulocytopenia and 4 out of 48 (8%) patients demonstrating grade IV thrombocytopenia. Two patients (4%) demonstrated partial response. Thirty patients have died and the Kaplan-Meier estimate of median survival is 9 months (95% confidence interval, 7-16 months). Topotecan in this dose and schedule does not appear active in patients with advanced colorectal cancer.

AB - The topoisomerase-1 inhibitor, topotecan, was tested in 48 eligible patients with advanced colorectal cancer. The patients had no prior chemotherapy and a Southwest Oncology Group performance status of 0-2. Topotecan was administered intravenously at 1.5 mg/m2/day for five days and repeated every 21 days. The major toxicity was hematologic with 19 out of 48 (40%) patients having grade IV granulocytopenia and 4 out of 48 (8%) patients demonstrating grade IV thrombocytopenia. Two patients (4%) demonstrated partial response. Thirty patients have died and the Kaplan-Meier estimate of median survival is 9 months (95% confidence interval, 7-16 months). Topotecan in this dose and schedule does not appear active in patients with advanced colorectal cancer.

KW - Colorectal cancer

KW - Topoisomerase-1 inhibitor

KW - Topotecan

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Phase II evaluation of topotecan in patients with advanced colorectal cancer. A Southwest Oncology Group trial (SWOG 9241)

Abstract

Keywords

ASJC Scopus subject areas

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