TY - JOUR
T1 - Phase II Feasibility Study of a Weight Loss Intervention in Female Breast and Colorectal Cancer Survivors (SWOG S1008)
AU - Greenlee, Heather
AU - Lew, Danika L.
AU - Hershman, Dawn L.
AU - Newman, Vicky A.
AU - Hansen, Lisa
AU - Hartman, Sheri J.
AU - Korner, Judith
AU - Shi, Zaixing
AU - Sardo Molmenti, Christine L.
AU - Sayegh, Antoine
AU - Fehrenbacher, Lou
AU - Lo, Shelly
AU - Klemp, Jennifer
AU - Rinn, Kristine
AU - Robertson, John M.
AU - Unger, Joseph
AU - Gralow, Julie
AU - Albain, Kathy
AU - Krouse, Robert
AU - Fabian, Carol
N1 - Funding Information:
Funding agencies: Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award numbers UG1CA189974, UG1CA189821, UG1CA189808, UG1CA189972, UG1CA190002, UG1CA189953, UG1CA189960, U10CA46282, U10CA13612, U10CA12644 and R21CA155973 and in part by contributions from Curves International. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or Curves International. Disclosure: The authors declare no conflict of interest. Clinical trial registration: NCT01453452. Additional Supporting Information may be found in the online version of this article. Received: 29 January 2018; Accepted: 24 June 2018. Published online 11 September 2018 doi:10.1002/oby.22269
PY - 2018/10
Y1 - 2018/10
N2 - Objective: This study aimed to test the feasibility of a 12-month weight loss intervention using telephone-based counseling plus community-situated physical activity (PA) in female breast cancer (BC) and colorectal cancer (CRC) survivors. Methods: This multisite cooperative group study enrolled sedentary, female, postmenopausal BC and CRC survivors with BMI ≥ 25 kg/m2 to receive 12-month fitness center memberships and telephone counseling encouraging 150 min/wk of PA and a 500-kcal/ddecrease in energy intake. Feasibility criteria included accrual, adherence, and retention. Target weight loss was ≥ 5%. Results: Among 25 BC survivors, median baseline BMI was 37.2 (range: 27.7-54.6), accrual occurred in 10 months, 60% and 28% met diet and exercise goals, 80% provided 12-month measures, and average weight loss was 7.6% (95% CI: −3.9%, 19.2%). Among 23 CRC survivors, median BMI was 31.8 (range: 26.4-48.7), accrual occurred in 24 months, 61% and 17% met diet and exercise goals, 87% provided measures, and average weight loss was 2.5% (95% CI: −8.2%, 13.3%). Conclusions: It is feasible to recruit and retain BC survivors in a cooperative group diet and PA weight loss trial. BC survivors achieved clinically meaningful weight loss but did not meet a priori adherence goals. In CRC survivors, recruitment was more difficult, and the intervention was less effective.
AB - Objective: This study aimed to test the feasibility of a 12-month weight loss intervention using telephone-based counseling plus community-situated physical activity (PA) in female breast cancer (BC) and colorectal cancer (CRC) survivors. Methods: This multisite cooperative group study enrolled sedentary, female, postmenopausal BC and CRC survivors with BMI ≥ 25 kg/m2 to receive 12-month fitness center memberships and telephone counseling encouraging 150 min/wk of PA and a 500-kcal/ddecrease in energy intake. Feasibility criteria included accrual, adherence, and retention. Target weight loss was ≥ 5%. Results: Among 25 BC survivors, median baseline BMI was 37.2 (range: 27.7-54.6), accrual occurred in 10 months, 60% and 28% met diet and exercise goals, 80% provided 12-month measures, and average weight loss was 7.6% (95% CI: −3.9%, 19.2%). Among 23 CRC survivors, median BMI was 31.8 (range: 26.4-48.7), accrual occurred in 24 months, 61% and 17% met diet and exercise goals, 87% provided measures, and average weight loss was 2.5% (95% CI: −8.2%, 13.3%). Conclusions: It is feasible to recruit and retain BC survivors in a cooperative group diet and PA weight loss trial. BC survivors achieved clinically meaningful weight loss but did not meet a priori adherence goals. In CRC survivors, recruitment was more difficult, and the intervention was less effective.
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U2 - 10.1002/oby.22269
DO - 10.1002/oby.22269
M3 - Article
C2 - 30272836
AN - SCOPUS:85053409568
VL - 26
SP - 1539
EP - 1549
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 10
ER -