Phase II Study of 13-cis-Retinoic Acid plus Interferon-α2a in Heavily Pretreated Squamous Carcinoma of the Cervix

Alton V. Hallum, David S Alberts, Scott M. Lippman, Lora Inclan, Glenn J. Shamdas, Joel M. Childers, Earl A. Surwit, Manuel Modiano, Kenneth D Hatch

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25 Scopus citations


The combination of 13-cis-retinoic acid (13-cRA) and interferon (IFN)-α2a has been reported to be highly active in previously untreated squamous carcinoma of the cervix. In this phase II study, 13-cRA was given at a dose of 1 mg/kg/day and IFNα-2a was given subcutaneously at a dose of 3 million units/m2/day. Thirteen of 14 patients enrolled in this study are evaluable for response and toxicity. There were no complete or partial responses. Ten patients had progressive disease and the remaining three had stable disease. Principle toxicities were fatigue, nausea, and vomiting. This regimen appears cross-resistant with radiotherapy and/or platinum-based cytotoxic therapy in heavily pretreated patients with squamous carcinoma of the cervix.

Original languageEnglish (US)
Pages (from-to)382-386
Number of pages5
JournalGynecologic Oncology
Issue number3
Publication statusPublished - Mar 1995


ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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