Phase II trial of 5-FU, vincristine, and mitomycin (FoMi) in metastatic bronchioloalveolar cell lung cancer: A southwest oncology group study

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Abstract

Twenty-three previously untreated patients with bronchioloalveolar cell lung cancer who had measurable disease and distant metastases (stage IIIM1, extensive) were treated with combination chemotherapy including 5-FU, vincristine, and mitomycin. Two of 23 patients (9%) achieved partial response lasting 5 and 6 months. Two patients (9%) died of sepsis while neutropenic. The current study does not justify the use of 5-FU, vincristine, and mitomycin combination chemotherapy in patients with metastatic bronchioloalveolar cell lung cancer.

Original languageEnglish (US)
Pages (from-to)1313-1314
Number of pages2
JournalCancer Treatment Reports
Volume69
Issue number11
StatePublished - 1985

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Mitomycin
Vincristine
Fluorouracil
Lung Neoplasms
Combination Drug Therapy
Sepsis
Neoplasm Metastasis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

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title = "Phase II trial of 5-FU, vincristine, and mitomycin (FoMi) in metastatic bronchioloalveolar cell lung cancer: A southwest oncology group study",
abstract = "Twenty-three previously untreated patients with bronchioloalveolar cell lung cancer who had measurable disease and distant metastases (stage IIIM1, extensive) were treated with combination chemotherapy including 5-FU, vincristine, and mitomycin. Two of 23 patients (9{\%}) achieved partial response lasting 5 and 6 months. Two patients (9{\%}) died of sepsis while neutropenic. The current study does not justify the use of 5-FU, vincristine, and mitomycin combination chemotherapy in patients with metastatic bronchioloalveolar cell lung cancer.",
author = "Miller, {Thomas P} and Livingston, {Robert B}",
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journal = "Journal of the National Cancer Institute",
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AU - Miller, Thomas P

AU - Livingston, Robert B

PY - 1985

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N2 - Twenty-three previously untreated patients with bronchioloalveolar cell lung cancer who had measurable disease and distant metastases (stage IIIM1, extensive) were treated with combination chemotherapy including 5-FU, vincristine, and mitomycin. Two of 23 patients (9%) achieved partial response lasting 5 and 6 months. Two patients (9%) died of sepsis while neutropenic. The current study does not justify the use of 5-FU, vincristine, and mitomycin combination chemotherapy in patients with metastatic bronchioloalveolar cell lung cancer.

AB - Twenty-three previously untreated patients with bronchioloalveolar cell lung cancer who had measurable disease and distant metastases (stage IIIM1, extensive) were treated with combination chemotherapy including 5-FU, vincristine, and mitomycin. Two of 23 patients (9%) achieved partial response lasting 5 and 6 months. Two patients (9%) died of sepsis while neutropenic. The current study does not justify the use of 5-FU, vincristine, and mitomycin combination chemotherapy in patients with metastatic bronchioloalveolar cell lung cancer.

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