Twenty‐five patients with unresectable and metastatic pancreatic carcinoma were treated with the combination of 5‐fluorouracil, Adriamycin, mitomycin C and streptozotocin (FAM‐S). Twelve of 25 patients responded (48%) and four patients demonstrated stable disease. Median survival of all patients was 6.75 months, and seven of 25 patients survived more than 12 months. Hematologic toxicity was moderate, and the predominant side effect recorded was nausea and vomiting (80% patients). Combination chemotherapy in pancreatic carcinoma may provide palliation and randomized trials are warranted to confirm these results.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jul 15 1982|
ASJC Scopus subject areas
- Cancer Research