Phase II trial of amonafide in previously treated patients with advanced ovarian cancer: A Southwest Oncology Group study

Holly H. Gallion, P. Y. Liu, David E. Alberts, Robert V. O'Toole, Janet O'Sullivan, Glenn Mills, Harriet O. Smith, Harry E. Hynes

Research output: Contribution to journalArticle

7 Scopus citations


Twenty-three patients with metastatic or recurrent Stage III or IV epithelial ovarian cancer who were refractory to or relapsed following previous chemotherapy with cisplatin or a cisplatin analog were entered into a phase II study of amonafide. The starting dose of amonafide was 300 mg/m2 delivered daily over 1 hr by intravenous infusion. In the absence of myelosuppression, the dose of amonafide was escalated by increments of 75 mg/m2 to a maximum of 450 mg/m2. There were 19 eligible and 17 fully evaluable patients. Grade 3 or 4 leukopenia occurred in 14 (74%) patients and grade 3 or 4 thrombocytopenia in 6 (32%) patients. No objective complete or partial responses were observed. Four patients had stable disease for 3, 4, 4.5, and 6 months, respectively. Therefore, amonafide in the doses used in the present trial does not have significant activity in previously treated patients with ovarian cancer.

Original languageEnglish (US)
Pages (from-to)230-232
Number of pages3
JournalGynecologic oncology
Issue number2
StatePublished - Aug 1992


ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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