Phase II trial of didemnin-B in advanced epithelial ovarian cancer - A Southwest Oncology Group Study

Joanna M. Cain; P. Y. Liu; David E. Alberts; Holly H. Gallion; Leslie Laufman; Janet O'Sullivan; Geoffrey Weiss; John N. Bickers

doi:10.1007/BF01275473

Phase II trial of didemnin-B in advanced epithelial ovarian cancer - A Southwest Oncology Group Study

Joanna M. Cain, P. Y. Liu, David E. Alberts, Holly H. Gallion, Leslie Laufman, Janet O'Sullivan, Geoffrey Weiss, John N. Bickers

Cancer Center

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A Phase II study of Didemnin-B, a marine cyclic depsipeptide, was undertaken in patients with progressive epithelial ovarian cancer. The starting dose was 2.6 mg/m². Fifteen patients received the drug, of whom twelve were evaluable. There were no responses observed in the twelve patients. The two most frequent toxicities were nausea and vomiting and anemia. On the basis of this trial, Didemnin-B is not felt to have significant effect with epithelial ovarian cancer.

Original language	English (US)
Pages (from-to)	23-24
Number of pages	2
Journal	Investigational New Drugs
Volume	10
Issue number	1
DOIs	https://doi.org/10.1007/BF01275473
State	Published - Mar 1992

Keywords

Didemnin-B
ovarian cancer

ASJC Scopus subject areas

Oncology
Pharmacology
Pharmacology (medical)

Access to Document

10.1007/BF01275473

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Phase II trial of didemnin-B in advanced epithelial ovarian cancer - A Southwest Oncology Group Study. / Cain, Joanna M.; Liu, P. Y.; Alberts, David E.; Gallion, Holly H.; Laufman, Leslie; O'Sullivan, Janet; Weiss, Geoffrey; Bickers, John N.

In: Investigational New Drugs, Vol. 10, No. 1, 03.1992, p. 23-24.

Research output: Contribution to journal › Article › peer-review

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