Phase II trial of didemnin-B in advanced epithelial ovarian cancer - A Southwest Oncology Group Study

Joanna M. Cain, P. Y. Liu, David S Alberts, Holly H. Gallion, Leslie Laufman, Janet O'Sullivan, Geoffrey Weiss, John N. Bickers

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A Phase II study of Didemnin-B, a marine cyclic depsipeptide, was undertaken in patients with progressive epithelial ovarian cancer. The starting dose was 2.6 mg/m2. Fifteen patients received the drug, of whom twelve were evaluable. There were no responses observed in the twelve patients. The two most frequent toxicities were nausea and vomiting and anemia. On the basis of this trial, Didemnin-B is not felt to have significant effect with epithelial ovarian cancer.

Original languageEnglish (US)
Pages (from-to)23-24
Number of pages2
JournalInvestigational New Drugs
Volume10
Issue number1
DOIs
StatePublished - Mar 1992

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didemnins
Depsipeptides
Nausea
Vomiting
Anemia
Pharmaceutical Preparations
Ovarian epithelial cancer

Keywords

  • Didemnin-B
  • ovarian cancer

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Phase II trial of didemnin-B in advanced epithelial ovarian cancer - A Southwest Oncology Group Study. / Cain, Joanna M.; Liu, P. Y.; Alberts, David S; Gallion, Holly H.; Laufman, Leslie; O'Sullivan, Janet; Weiss, Geoffrey; Bickers, John N.

In: Investigational New Drugs, Vol. 10, No. 1, 03.1992, p. 23-24.

Research output: Contribution to journalArticle

Cain, JM, Liu, PY, Alberts, DS, Gallion, HH, Laufman, L, O'Sullivan, J, Weiss, G & Bickers, JN 1992, 'Phase II trial of didemnin-B in advanced epithelial ovarian cancer - A Southwest Oncology Group Study', Investigational New Drugs, vol. 10, no. 1, pp. 23-24. https://doi.org/10.1007/BF01275473
Cain, Joanna M. ; Liu, P. Y. ; Alberts, David S ; Gallion, Holly H. ; Laufman, Leslie ; O'Sullivan, Janet ; Weiss, Geoffrey ; Bickers, John N. / Phase II trial of didemnin-B in advanced epithelial ovarian cancer - A Southwest Oncology Group Study. In: Investigational New Drugs. 1992 ; Vol. 10, No. 1. pp. 23-24.
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