Phase II trial of vinblastine in previously treated patients with ovarian cancer: A southwest oncology group study

E. A. Surwit, D. S. Alberts, R. V. O'Toole, V. Graham, E. V. Hannigan, R. L. Stephens, J. G. Boutselis

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Sixty-eight patients with relapsing, epithelial type ovarian carcinoma were entered into a Phase II study of vinblastine. Vinblastine was administered as a continuous intravenous infusion over 5 days at a starting dose of 1.7 mg/m2/day every 3 weeks. There were 44 fully evaluable and 6 partially evaluable patients. Forty-one of these patients had had only one prior treatment regimen. Grade 3 or 4 leukopenia occurred in 12 patients (24%), but Grade 3 or 4 thrombocytopenia occurred in only 2 patients. There were two clinical complete responses of 18- and 36-week durations and one partial response of 6 weeks for an overall response rate of 7%. We conclude that vinblastine, administered in optimal dose and schedule, has little clinical activity in previously treated patients with ovarian cancer.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalGynecologic oncology
Volume28
Issue number1
DOIs
StatePublished - Sep 1987

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Phase II trial of vinblastine in previously treated patients with ovarian cancer: A southwest oncology group study'. Together they form a unique fingerprint.

Cite this