Abstract
Sixty-eight patients with relapsing, epithelial type ovarian carcinoma were entered into a Phase II study of vinblastine. Vinblastine was administered as a continuous intravenous infusion over five days at a starting dose of 1.7 mg/m2/day every 3 weeks. There were 44 fully evaluable and 6 partially evaluable patients. Forty-one of these patients had had only one prior treatment regimen. Grade 3 or 4 leukopenia occurred in 12 patients (24%), but Grade 3 or 4 thrombocytopenia occurred in only 2 patients. There were two clinical complete responses of 18 and 36 weeks duration and one partial response of 6 weeks for an overall response rate of 7%. We conclude that vinblastine, administered in optimal dose and schedule, has little clinical activity in previously treated patients with ovarian cancer.
Original language | English (US) |
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Pages (from-to) | 214-219 |
Number of pages | 6 |
Journal | Gynecologic oncology |
Volume | 27 |
Issue number | 2 |
DOIs | |
State | Published - Jun 1987 |
ASJC Scopus subject areas
- Oncology
- Obstetrics and Gynecology