Phase II trial of vinblastine in previously treated patients with ovarian cancer: A Southwest Oncology Group study

E. A. Surwit; D. S. Alberts; R. V. O'Toole; V. Graham; E. V. Hannigan; R. L. Stephens; J. G. Boutselis

doi:10.1016/0090-8258(87)90295-2

Phase II trial of vinblastine in previously treated patients with ovarian cancer: A Southwest Oncology Group study

E. A. Surwit, D. S. Alberts, R. V. O'Toole, V. Graham, E. V. Hannigan, R. L. Stephens, J. G. Boutselis

Cancer Center

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Abstract

Sixty-eight patients with relapsing, epithelial type ovarian carcinoma were entered into a Phase II study of vinblastine. Vinblastine was administered as a continuous intravenous infusion over five days at a starting dose of 1.7 mg/m²/day every 3 weeks. There were 44 fully evaluable and 6 partially evaluable patients. Forty-one of these patients had had only one prior treatment regimen. Grade 3 or 4 leukopenia occurred in 12 patients (24%), but Grade 3 or 4 thrombocytopenia occurred in only 2 patients. There were two clinical complete responses of 18 and 36 weeks duration and one partial response of 6 weeks for an overall response rate of 7%. We conclude that vinblastine, administered in optimal dose and schedule, has little clinical activity in previously treated patients with ovarian cancer.

Original language	English (US)
Pages (from-to)	214-219
Number of pages	6
Journal	Gynecologic oncology
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/0090-8258(87)90295-2
State	Published - Jun 1987

ASJC Scopus subject areas

Oncology
Obstetrics and Gynecology

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title = "Phase II trial of vinblastine in previously treated patients with ovarian cancer: A Southwest Oncology Group study",

abstract = "Sixty-eight patients with relapsing, epithelial type ovarian carcinoma were entered into a Phase II study of vinblastine. Vinblastine was administered as a continuous intravenous infusion over five days at a starting dose of 1.7 mg/m2/day every 3 weeks. There were 44 fully evaluable and 6 partially evaluable patients. Forty-one of these patients had had only one prior treatment regimen. Grade 3 or 4 leukopenia occurred in 12 patients (24%), but Grade 3 or 4 thrombocytopenia occurred in only 2 patients. There were two clinical complete responses of 18 and 36 weeks duration and one partial response of 6 weeks for an overall response rate of 7%. We conclude that vinblastine, administered in optimal dose and schedule, has little clinical activity in previously treated patients with ovarian cancer.",

author = "Surwit, {E. A.} and Alberts, {D. S.} and O'Toole, {R. V.} and V. Graham and Hannigan, {E. V.} and Stephens, {R. L.} and Boutselis, {J. G.}",

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T2 - A Southwest Oncology Group study

AU - Surwit, E. A.

AU - Alberts, D. S.

AU - O'Toole, R. V.

AU - Graham, V.

AU - Hannigan, E. V.

AU - Stephens, R. L.

AU - Boutselis, J. G.

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AB - Sixty-eight patients with relapsing, epithelial type ovarian carcinoma were entered into a Phase II study of vinblastine. Vinblastine was administered as a continuous intravenous infusion over five days at a starting dose of 1.7 mg/m2/day every 3 weeks. There were 44 fully evaluable and 6 partially evaluable patients. Forty-one of these patients had had only one prior treatment regimen. Grade 3 or 4 leukopenia occurred in 12 patients (24%), but Grade 3 or 4 thrombocytopenia occurred in only 2 patients. There were two clinical complete responses of 18 and 36 weeks duration and one partial response of 6 weeks for an overall response rate of 7%. We conclude that vinblastine, administered in optimal dose and schedule, has little clinical activity in previously treated patients with ovarian cancer.

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Phase II trial of vinblastine in previously treated patients with ovarian cancer: A Southwest Oncology Group study

Abstract

ASJC Scopus subject areas

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