Phase II trial of vinblastine in previously treated patients with ovarian cancer: A Southwest Oncology Group study

E. A. Surwit, D. S. Alberts, R. V. O'Toole, V. Graham, E. V. Hannigan, R. L. Stephens, J. G. Boutselis

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Sixty-eight patients with relapsing, epithelial type ovarian carcinoma were entered into a Phase II study of vinblastine. Vinblastine was administered as a continuous intravenous infusion over five days at a starting dose of 1.7 mg/m2/day every 3 weeks. There were 44 fully evaluable and 6 partially evaluable patients. Forty-one of these patients had had only one prior treatment regimen. Grade 3 or 4 leukopenia occurred in 12 patients (24%), but Grade 3 or 4 thrombocytopenia occurred in only 2 patients. There were two clinical complete responses of 18 and 36 weeks duration and one partial response of 6 weeks for an overall response rate of 7%. We conclude that vinblastine, administered in optimal dose and schedule, has little clinical activity in previously treated patients with ovarian cancer.

Original languageEnglish (US)
Pages (from-to)214-219
Number of pages6
JournalGynecologic oncology
Volume27
Issue number2
DOIs
StatePublished - Jun 1987

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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