Phase precession and variable spatial scaling in a periodic attractor map model of medial entorhinal grid cells with realistic after-spike dynamics

Zaneta Navratilova, Lisa M. Giocomo, Jean-Marc Fellous, Michael E. Hasselmo, Bruce L. McNaughton

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

We present a model that describes the generation of the spatial (grid fields) and temporal (phase precession) properties of medial entorhinal cortical (MEC) neurons by combining network and intrinsic cellular properties. The model incorporates network architecture derived from earlier attractor map models, and is implemented in 1D for simplicity. Periodic driving of conjunctive (position × head-direction) layer-III MEC cells at theta frequency with intensity proportional to the rat's speed, moves an 'activity bump' forward in network space at a corresponding speed. The addition of prolonged excitatory currents and simple after-spike dynamics resembling those observed in MEC stellate cells (for which new data are presented) accounts for both phase precession and the change in scale of grid fields along the dorso-ventral axis of MEC. Phase precession in the model depends on both synaptic connectivity and intrinsic currents, each of which drive neural spiking either during entry into, or during exit out of a grid field. Thus, the model predicts that the slope of phase precession changes between entry into and exit out of the field. The model also exhibits independent variation in grid spatial period and grid field size, which suggests possible experimental tests of the model.

Original languageEnglish (US)
Pages (from-to)772-789
Number of pages18
JournalHippocampus
Volume22
Issue number4
DOIs
StatePublished - Apr 2012

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Theoretical Models
Head
Neurons
Grid Cells
Direction compound

Keywords

  • Continuous attractor neural network
  • Dead reckoning
  • Entorhinal stellate cells
  • Path integration
  • Place cells

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Phase precession and variable spatial scaling in a periodic attractor map model of medial entorhinal grid cells with realistic after-spike dynamics. / Navratilova, Zaneta; Giocomo, Lisa M.; Fellous, Jean-Marc; Hasselmo, Michael E.; McNaughton, Bruce L.

In: Hippocampus, Vol. 22, No. 4, 04.2012, p. 772-789.

Research output: Contribution to journalArticle

Navratilova, Zaneta ; Giocomo, Lisa M. ; Fellous, Jean-Marc ; Hasselmo, Michael E. ; McNaughton, Bruce L. / Phase precession and variable spatial scaling in a periodic attractor map model of medial entorhinal grid cells with realistic after-spike dynamics. In: Hippocampus. 2012 ; Vol. 22, No. 4. pp. 772-789.
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