Phase Space Bottlenecks in Enzymatic Reactions

Dimitri Antoniou, Steven D Schwartz

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The definition of a transition state on an individual reactive trajectory is made via a committor analysis. In the past, the bottleneck definition has often been applied in configuration space. This is an approximation, and in order to expand this definition, we are revisiting an enzyme in which we had identified a fast subpicosecond motion that makes the reaction possible. First we used a time-series analysis method to identify the exact time when this motion initiates donor-acceptor compression. Then we modified the standard committor analysis of transition path sampling to identify events in phase space and found that there is a dividing surface in phase space significantly earlier than the configurationally defined transition-state crossing.

Original languageEnglish (US)
Pages (from-to)433-439
Number of pages7
JournalJournal of Physical Chemistry B
Volume120
Issue number3
DOIs
StatePublished - Jan 28 2016

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Materials Chemistry
  • Surfaces, Coatings and Films

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