Phencyclidine binding sites in the nucleus accumbens and phencyclidine-induced hyperactivity are decreased following lesions of the mesolimbic dopamine system

Edward D. French, Carmencita Pilapil, Remi Quirion

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Abstract

[3H]Phencyclidine ([3H]PCP) binding to rat nucleus accumbens, hippocampal and striatal membranes, and PCP-induced locomotor hyperactivity were assessed following selective lesions of the mesolimbic dopaminergic system. 6-Hydroxydopamine (6-OHDA) injections into the A10 region of the ventral tegmental area or into the accumbens itself resulted in a blockade of PCP's stimulatory effects and a highly significant reduction in the number of [3H]PCP binding sites and dopamine content of the nucleus accumbens. However, destruction of the dopaminergic mesolimbic fibers did not significantly alter hippocampal or striatal [3H]PCP binding. The data suggest that PCP elicits its locomotor stimulating effects via an interaction with PCP binding sites located mostly on mesolimbic dopaminergic terminals within the nucleus accumbens.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalEuropean Journal of Pharmacology
Volume116
Issue number1-2
DOIs
StatePublished - Oct 8 1985

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Keywords

  • Lesions 6-Hydroxydopamine
  • Locomotion
  • Nucleus accumbens
  • PCP-binding sites
  • Phencyclidine (PCP)
  • Ventral tegmental area

ASJC Scopus subject areas

  • Pharmacology

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