Phencyclidine (PCP) disposition kinetics in dogs: Preliminary observations

J. R. Woodworth, S. M. Owens, M. Mayersohn

Research output: Contribution to journalArticle

Abstract

Phencyclidine (PCP) disposition kinetics was examined in 5 dogs after administration of 1 mg/kg doses as an intravenous bolus. PCP undergoes a pronounced distributive phase and has a large volume of distribution (ca 25 L/kg). The elimination half-life is highly variable, ranging from 2.6 to 13.5 hours. Total body clearance is a large value (ca 45 ml/min/kg), whereas renal clearance (determined in 2 dogs) represents only a small percentage of total clearance (0.7-1.9%).

Original languageEnglish (US)
Pages (from-to)49-58
Number of pages10
JournalResearch Communications in Substances of Abuse
Volume4
Issue number1
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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