Phencyclidine (PCP) disposition kinetics was examined in 5 dogs after administration of 1 mg/kg doses as an intravenous bolus. PCP undergoes a pronounced distributive phase and has a large volume of distribution (ca 25 L/kg). The elimination half-life is highly variable, ranging from 2.6 to 13.5 hours. Total body clearance is a large value (ca 45 ml/min/kg), whereas renal clearance (determined in 2 dogs) represents only a small percentage of total clearance (0.7-1.9%).
|Original language||English (US)|
|Number of pages||10|
|Journal||Research Communications in Substances of Abuse|
|State||Published - Jan 1 1983|
ASJC Scopus subject areas
- Medicine (miscellaneous)