Phenotypic and functional stages in the intrathymic development of αβ T cells

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156 Citations (Scopus)

Abstract

The thymus is the main site o f T-cell maturation. On arrival in the thymus, CD8-CD4- double-negative (DN) T-cell precursors undergo extensive gene rearrangement, phenotypic alteration and biochemical modi fication to yield the population of thymocytes that undergoes intrathymic selection. The selected mature thymocytes then go on to seed the periphery. In this article Janko Nikolić-Žugić discusses the labyrinthine development that constitutes αβ T-cell maturation and selection.

Original languageEnglish (US)
Pages (from-to)65-70
Number of pages6
JournalImmunology Today
Volume12
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

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Thymocytes
Thymus Gland
T-Lymphoid Precursor Cells
T-Lymphocytes
Gene Rearrangement
Seeds
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Phenotypic and functional stages in the intrathymic development of αβ T cells. / Nikolich-Zugich, Janko.

In: Immunology Today, Vol. 12, No. 2, 1991, p. 65-70.

Research output: Contribution to journalArticle

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