Phenytoin and fosphenytoin: A model of cost and clinical outcomes

Edward P Armstrong, Karen Ann Sauer, Madeline J. Downey

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We developed a pharmacoeconomic model to compare costs and clinical outcomes of administering phenytoin and fosphenytoin alone and in combination in hospitalized patients. Effectiveness data were obtained by distributing a questionnaire to 33 registered nurses at three acute care hospitals who worked in critical care, neurology services, or emergency department. The questionnaire addressed methods of phenytoin and fosphenytoin administration, frequency of adverse reactions, methods of treating adverse reactions, and demographic information. The model estimated that if 50% of phenytoin loading doses were substituted with fosphenytoin, a reduction in adverse events resulted in an estimated increase of $36/patient cost to the hospital. If phenytoin maintenance dosages were substituted with fosphenytoin, the model predicted essentially no change in cost to the hospital. It appears that fosphenytoin reduces adverse events at a reasonable increase in total hospital costs.

Original languageEnglish (US)
Pages (from-to)844-853
Number of pages10
JournalPharmacotherapy
Volume19
Issue number7
DOIs
StatePublished - 1999

Fingerprint

Phenytoin
Hospital Costs
Costs and Cost Analysis
Pharmaceutical Economics
Critical Care
Neurology
Hospital Emergency Service
Nurses
Maintenance
Demography
fosphenytoin
Surveys and Questionnaires

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Phenytoin and fosphenytoin : A model of cost and clinical outcomes. / Armstrong, Edward P; Sauer, Karen Ann; Downey, Madeline J.

In: Pharmacotherapy, Vol. 19, No. 7, 1999, p. 844-853.

Research output: Contribution to journalArticle

Armstrong, Edward P ; Sauer, Karen Ann ; Downey, Madeline J. / Phenytoin and fosphenytoin : A model of cost and clinical outcomes. In: Pharmacotherapy. 1999 ; Vol. 19, No. 7. pp. 844-853.
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