Phenytoin-induced methadone withdrawal

Theodore G Tong, S. M. Pond, M. J. Kreek, N. F. Jaffery, N. L. Benowitz

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Methadone-maintained volunteers experienced moderately severe opiate withdrawal symptoms within 3 or 4 days of beginning phenytoin in therapeutic doses. The area under the methadone plasma concentration-time curve decreased while the ratio of the pyrrolidine-to-metabolite excretion in urine to this area increased significantly. This suggests that phenytoin accelerates methadone metabolism. Methadone dosing adjustments should be anticipated when phenytoin is initiated or discontinued in methadone-maintained patients.

Original languageEnglish (US)
Pages (from-to)349-351
Number of pages3
JournalAnnals of Internal Medicine
Volume94
Issue number3
StatePublished - 1981
Externally publishedYes

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Methadone
Phenytoin
Opiate Alkaloids
Social Adjustment
Substance Withdrawal Syndrome
Volunteers
Urine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tong, T. G., Pond, S. M., Kreek, M. J., Jaffery, N. F., & Benowitz, N. L. (1981). Phenytoin-induced methadone withdrawal. Annals of Internal Medicine, 94(3), 349-351.

Phenytoin-induced methadone withdrawal. / Tong, Theodore G; Pond, S. M.; Kreek, M. J.; Jaffery, N. F.; Benowitz, N. L.

In: Annals of Internal Medicine, Vol. 94, No. 3, 1981, p. 349-351.

Research output: Contribution to journalArticle

Tong, TG, Pond, SM, Kreek, MJ, Jaffery, NF & Benowitz, NL 1981, 'Phenytoin-induced methadone withdrawal', Annals of Internal Medicine, vol. 94, no. 3, pp. 349-351.
Tong TG, Pond SM, Kreek MJ, Jaffery NF, Benowitz NL. Phenytoin-induced methadone withdrawal. Annals of Internal Medicine. 1981;94(3):349-351.
Tong, Theodore G ; Pond, S. M. ; Kreek, M. J. ; Jaffery, N. F. ; Benowitz, N. L. / Phenytoin-induced methadone withdrawal. In: Annals of Internal Medicine. 1981 ; Vol. 94, No. 3. pp. 349-351.
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