Phenytoin-induced methadone withdrawal

T. G. Tong, S. M. Pond, M. J. Kreek, N. F. Jaffery, N. L. Benowitz

Research output: Contribution to journalArticle

93 Scopus citations


Methadone-maintained volunteers experienced moderately severe opiate withdrawal symptoms within 3 or 4 days of beginning phenytoin in therapeutic doses. The area under the methadone plasma concentration-time curve decreased while the ratio of the pyrrolidine-to-metabolite excretion in urine to this area increased significantly. This suggests that phenytoin accelerates methadone metabolism. Methadone dosing adjustments should be anticipated when phenytoin is initiated or discontinued in methadone-maintained patients.

Original languageEnglish (US)
Pages (from-to)349-351
Number of pages3
JournalUnknown Journal
Issue number3
StatePublished - Jan 1 1981
Externally publishedYes


ASJC Scopus subject areas

  • Internal Medicine

Cite this

Tong, T. G., Pond, S. M., Kreek, M. J., Jaffery, N. F., & Benowitz, N. L. (1981). Phenytoin-induced methadone withdrawal. Unknown Journal, 94(3), 349-351.