Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751

E. M Kithsiri Wijeratne, Hongping He, Scott G. Franzblau, Angela M. Hoffman, Leslie Gunatilaka

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.

Original languageEnglish (US)
Pages (from-to)1860-1865
Number of pages6
JournalJournal of Natural Products
Volume76
Issue number10
DOIs
StatePublished - Oct 25 2013

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Bearings (structural)
Methylation
Spectroscopic analysis
Fungi
Alkaloids
Derivatives
Mycelium
fluorene
phomapyrrolidone A
phomapyrrolidone B
phomapyrrolidone C

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751. / Wijeratne, E. M Kithsiri; He, Hongping; Franzblau, Scott G.; Hoffman, Angela M.; Gunatilaka, Leslie.

In: Journal of Natural Products, Vol. 76, No. 10, 25.10.2013, p. 1860-1865.

Research output: Contribution to journalArticle

Wijeratne, E. M Kithsiri ; He, Hongping ; Franzblau, Scott G. ; Hoffman, Angela M. ; Gunatilaka, Leslie. / Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751. In: Journal of Natural Products. 2013 ; Vol. 76, No. 10. pp. 1860-1865.
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