Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751

E. M.Kithsiri Wijeratne; Hongping He; Scott G. Franzblau; Angela M. Hoffman; A. A.Leslie Gunatilaka

doi:10.1021/np400391p

Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751

E. M.Kithsiri Wijeratne, Hongping He, Scott G. Franzblau, Angela M. Hoffman, A. A.Leslie Gunatilaka

Natural Resources and the Environment, School of

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.

Original language	English (US)
Pages (from-to)	1860-1865
Number of pages	6
Journal	Journal Of Natural Products
Volume	76
Issue number	10
DOIs	https://doi.org/10.1021/np400391p
State	Published - Oct 25 2013

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np400391p

Cite this

@article{d85b2190e4684350b7031657128c8282,

title = "Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751",

abstract = "Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.",

author = "Wijeratne, {E. M.Kithsiri} and Hongping He and Franzblau, {Scott G.} and Hoffman, {Angela M.} and Gunatilaka, {A. A.Leslie}",

year = "2013",

month = oct,

day = "25",

doi = "10.1021/np400391p",

language = "English (US)",

volume = "76",

pages = "1860--1865",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "10",

}

TY - JOUR

T1 - Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751

AU - Wijeratne, E. M.Kithsiri

AU - He, Hongping

AU - Franzblau, Scott G.

AU - Hoffman, Angela M.

AU - Gunatilaka, A. A.Leslie

PY - 2013/10/25

Y1 - 2013/10/25

N2 - Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.

AB - Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.

UR - http://www.scopus.com/inward/record.url?scp=84886852029&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886852029&partnerID=8YFLogxK

U2 - 10.1021/np400391p

DO - 10.1021/np400391p

M3 - Article

C2 - 24079882

AN - SCOPUS:84886852029

VL - 76

SP - 1860

EP - 1865

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 10

ER -

Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this