Abstract
Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1860-1865 |
| Number of pages | 6 |
| Journal | Journal Of Natural Products |
| Volume | 76 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 25 2013 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Cite this
Wijeratne, E. M. K., He, H., Franzblau, S. G., Hoffman, A. M., & Gunatilaka, A. A. L. (2013). Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751. Journal Of Natural Products, 76(10), 1860-1865. https://doi.org/10.1021/np400391p