Abstract
Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1860-1865 |
| Number of pages | 6 |
| Journal | Journal of Natural Products |
| Volume | 76 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 25 2013 |
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ASJC Scopus subject areas
- Complementary and alternative medicine
- Molecular Medicine
- Organic Chemistry
- Analytical Chemistry
- Pharmaceutical Science
- Pharmacology
- Drug Discovery
Cite this
Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751. / Wijeratne, E. M Kithsiri; He, Hongping; Franzblau, Scott G.; Hoffman, Angela M.; Gunatilaka, Leslie.
In: Journal of Natural Products, Vol. 76, No. 10, 25.10.2013, p. 1860-1865.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Phomapyrrolidones A-C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751
AU - Wijeratne, E. M Kithsiri
AU - He, Hongping
AU - Franzblau, Scott G.
AU - Hoffman, Angela M.
AU - Gunatilaka, Leslie
PY - 2013/10/25
Y1 - 2013/10/25
N2 - Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.
AB - Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.
UR - http://www.scopus.com/inward/record.url?scp=84886852029&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886852029&partnerID=8YFLogxK
U2 - 10.1021/np400391p
DO - 10.1021/np400391p
M3 - Article
C2 - 24079882
AN - SCOPUS:84886852029
VL - 76
SP - 1860
EP - 1865
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 10
ER -