Phospholipase A2s in cell injury and death

B. S. Cummings, J. McHowat, R. G. Schnellmann

Research output: Contribution to journalReview articlepeer-review

216 Scopus citations

Abstract

Phospholipase A2s (PLA2s) represent a family of esterases that hydrolyze the sn-2 ester bond in phospholipids, releasing free fatty acids and lysophospholipids. PLA2s are important in the signaling of several cellular processes and are known to play a significant role in inflammation. Studies also show that PLA2s are modulators of drug-, chemical-, and ischemia/reperfusion-induced cellular injury. The role of PLA2s in apoptosis and oncosis depends upon the PLA2 isoform, the cell type, and the stimulus of injury. The purpose of this review is to discuss the functions of iPLA2, cPLA2 and sPLA2 isoforms in oncosis and apoptosis, including oxidant-induced and receptor-mediated cell death. In addition, the measurement and modulation of PLA2 is discussed.

Original languageEnglish (US)
Pages (from-to)793-799
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Volume294
Issue number3
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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