Phosphorus: Basic Nutritional Aspects

Pawel R Kiela, Vijayababu M. Radhakrishnan, Fayez K Ghishan

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Phosphorus is one of the most abundant minerals in the body, with the majority of it stored in bone and teeth. Maintenance of extracellular and intracellular phosphate levels within a narrow range is important for many biological processes, including energy metabolism, cell signaling, regulation of protein synthesis, skeletal development, and bone integrity. Three major mechanisms are responsible for the maintenance of systemic phosphate homeostasis: intestinal uptake, retention or release from the bone, and renal reabsorption. The currently known main regulators of phosphate homeostasis include parathyroid hormone, vitamin D, fibroblast growth factor-23, and Klotho. Growth, aging, and genetic and metabolic disorders can all significantly alter systemic phosphate balance. The recommended dietary allowance, 700. mg/day of phosphorus for healthy adults, is meant to maintain serum phosphorus concentrations within the physiologic range of 2.5-4.5. mg/dL. Along with additives in processed foods, dietary sources of phosphorous include meat, poultry, fish, eggs, dairy products, beans, and seeds, and nutritional phosphate deficiency is uncommon. However, several clinical disorders may affect intestinal or renal phosphate (re)absorption and contribute to hyper- or hypophosphatemia. Patients with chronic kidney disease, with renal failure, and/or on dialysis benefit from reduced phosphorus intake. In this chapter we provide a brief review of the physiological and nutritional aspects of phosphorus as well as key factors involved in the maintenance of its homeostasis, and we outline disorders associated with pathophysiological changes in systemic phosphate balance.

Original languageEnglish (US)
Title of host publicationMolecular, Genetic, and Nutritional Aspects of Major and Trace Minerals
PublisherElsevier Inc.
Pages413-427
Number of pages15
ISBN (Electronic)9780128023761
ISBN (Print)9780128021682
DOIs
StatePublished - Sep 29 2016

Fingerprint

Phosphorus
Phosphates
Homeostasis
Maintenance
Hyperphosphatemia
Hypophosphatemia
Biological Phenomena
Bone and Bones
Recommended Dietary Allowances
Inborn Genetic Diseases
Dairy Products
Bone Development
Poultry
Parathyroid Hormone
Chronic Renal Insufficiency
Vitamin D
Malnutrition
Meat
Energy Metabolism
Eggs

Keywords

  • Absorption
  • Dietary phosphate
  • Genetics
  • Hypophosphatemia
  • Inorganic phosphate
  • Phosphate homeostasis
  • Phosphate intake
  • Rickets
  • Secretion

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kiela, P. R., Radhakrishnan, V. M., & Ghishan, F. K. (2016). Phosphorus: Basic Nutritional Aspects. In Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals (pp. 413-427). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802168-2.00034-8

Phosphorus : Basic Nutritional Aspects. / Kiela, Pawel R; Radhakrishnan, Vijayababu M.; Ghishan, Fayez K.

Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Elsevier Inc., 2016. p. 413-427.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kiela, PR, Radhakrishnan, VM & Ghishan, FK 2016, Phosphorus: Basic Nutritional Aspects. in Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Elsevier Inc., pp. 413-427. https://doi.org/10.1016/B978-0-12-802168-2.00034-8
Kiela PR, Radhakrishnan VM, Ghishan FK. Phosphorus: Basic Nutritional Aspects. In Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Elsevier Inc. 2016. p. 413-427 https://doi.org/10.1016/B978-0-12-802168-2.00034-8
Kiela, Pawel R ; Radhakrishnan, Vijayababu M. ; Ghishan, Fayez K. / Phosphorus : Basic Nutritional Aspects. Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Elsevier Inc., 2016. pp. 413-427
@inbook{79a9e32c974546e0981243ff883da202,
title = "Phosphorus: Basic Nutritional Aspects",
abstract = "Phosphorus is one of the most abundant minerals in the body, with the majority of it stored in bone and teeth. Maintenance of extracellular and intracellular phosphate levels within a narrow range is important for many biological processes, including energy metabolism, cell signaling, regulation of protein synthesis, skeletal development, and bone integrity. Three major mechanisms are responsible for the maintenance of systemic phosphate homeostasis: intestinal uptake, retention or release from the bone, and renal reabsorption. The currently known main regulators of phosphate homeostasis include parathyroid hormone, vitamin D, fibroblast growth factor-23, and Klotho. Growth, aging, and genetic and metabolic disorders can all significantly alter systemic phosphate balance. The recommended dietary allowance, 700. mg/day of phosphorus for healthy adults, is meant to maintain serum phosphorus concentrations within the physiologic range of 2.5-4.5. mg/dL. Along with additives in processed foods, dietary sources of phosphorous include meat, poultry, fish, eggs, dairy products, beans, and seeds, and nutritional phosphate deficiency is uncommon. However, several clinical disorders may affect intestinal or renal phosphate (re)absorption and contribute to hyper- or hypophosphatemia. Patients with chronic kidney disease, with renal failure, and/or on dialysis benefit from reduced phosphorus intake. In this chapter we provide a brief review of the physiological and nutritional aspects of phosphorus as well as key factors involved in the maintenance of its homeostasis, and we outline disorders associated with pathophysiological changes in systemic phosphate balance.",
keywords = "Absorption, Dietary phosphate, Genetics, Hypophosphatemia, Inorganic phosphate, Phosphate homeostasis, Phosphate intake, Rickets, Secretion",
author = "Kiela, {Pawel R} and Radhakrishnan, {Vijayababu M.} and Ghishan, {Fayez K}",
year = "2016",
month = "9",
day = "29",
doi = "10.1016/B978-0-12-802168-2.00034-8",
language = "English (US)",
isbn = "9780128021682",
pages = "413--427",
booktitle = "Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals",
publisher = "Elsevier Inc.",
address = "United States",

}

TY - CHAP

T1 - Phosphorus

T2 - Basic Nutritional Aspects

AU - Kiela, Pawel R

AU - Radhakrishnan, Vijayababu M.

AU - Ghishan, Fayez K

PY - 2016/9/29

Y1 - 2016/9/29

N2 - Phosphorus is one of the most abundant minerals in the body, with the majority of it stored in bone and teeth. Maintenance of extracellular and intracellular phosphate levels within a narrow range is important for many biological processes, including energy metabolism, cell signaling, regulation of protein synthesis, skeletal development, and bone integrity. Three major mechanisms are responsible for the maintenance of systemic phosphate homeostasis: intestinal uptake, retention or release from the bone, and renal reabsorption. The currently known main regulators of phosphate homeostasis include parathyroid hormone, vitamin D, fibroblast growth factor-23, and Klotho. Growth, aging, and genetic and metabolic disorders can all significantly alter systemic phosphate balance. The recommended dietary allowance, 700. mg/day of phosphorus for healthy adults, is meant to maintain serum phosphorus concentrations within the physiologic range of 2.5-4.5. mg/dL. Along with additives in processed foods, dietary sources of phosphorous include meat, poultry, fish, eggs, dairy products, beans, and seeds, and nutritional phosphate deficiency is uncommon. However, several clinical disorders may affect intestinal or renal phosphate (re)absorption and contribute to hyper- or hypophosphatemia. Patients with chronic kidney disease, with renal failure, and/or on dialysis benefit from reduced phosphorus intake. In this chapter we provide a brief review of the physiological and nutritional aspects of phosphorus as well as key factors involved in the maintenance of its homeostasis, and we outline disorders associated with pathophysiological changes in systemic phosphate balance.

AB - Phosphorus is one of the most abundant minerals in the body, with the majority of it stored in bone and teeth. Maintenance of extracellular and intracellular phosphate levels within a narrow range is important for many biological processes, including energy metabolism, cell signaling, regulation of protein synthesis, skeletal development, and bone integrity. Three major mechanisms are responsible for the maintenance of systemic phosphate homeostasis: intestinal uptake, retention or release from the bone, and renal reabsorption. The currently known main regulators of phosphate homeostasis include parathyroid hormone, vitamin D, fibroblast growth factor-23, and Klotho. Growth, aging, and genetic and metabolic disorders can all significantly alter systemic phosphate balance. The recommended dietary allowance, 700. mg/day of phosphorus for healthy adults, is meant to maintain serum phosphorus concentrations within the physiologic range of 2.5-4.5. mg/dL. Along with additives in processed foods, dietary sources of phosphorous include meat, poultry, fish, eggs, dairy products, beans, and seeds, and nutritional phosphate deficiency is uncommon. However, several clinical disorders may affect intestinal or renal phosphate (re)absorption and contribute to hyper- or hypophosphatemia. Patients with chronic kidney disease, with renal failure, and/or on dialysis benefit from reduced phosphorus intake. In this chapter we provide a brief review of the physiological and nutritional aspects of phosphorus as well as key factors involved in the maintenance of its homeostasis, and we outline disorders associated with pathophysiological changes in systemic phosphate balance.

KW - Absorption

KW - Dietary phosphate

KW - Genetics

KW - Hypophosphatemia

KW - Inorganic phosphate

KW - Phosphate homeostasis

KW - Phosphate intake

KW - Rickets

KW - Secretion

UR - http://www.scopus.com/inward/record.url?scp=85024391867&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85024391867&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-802168-2.00034-8

DO - 10.1016/B978-0-12-802168-2.00034-8

M3 - Chapter

AN - SCOPUS:85024391867

SN - 9780128021682

SP - 413

EP - 427

BT - Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals

PB - Elsevier Inc.

ER -