Phototriggering of geometric dendrimer disassembly: An improved synthesis of 2,4-bis(hydroxymethyl)phenol based dendrimers

Michael L. Szalai, Dominic V. McGrath

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Dendrimers capable of phototriggered disassembly were prepared up to the second-generation using an improved synthesis of 2,4-bis(hydroxymethyl)phenol based dendrimers. It was found that disassembly proceeds to 75-80% completion after 2 h of irradiation at 310 nm for all molecules studied. The lack of complete reaction is attributed to an inefficient photochemical deprotection process rather than the disassembly itself.

Original languageEnglish (US)
Pages (from-to)7261-7266
Number of pages6
JournalTetrahedron
Volume60
Issue number34
DOIs
StatePublished - Aug 16 2004

Keywords

  • Dendrimers
  • Disassembly
  • Tetrahydrofuran

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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