Phylogenetic evidence for recombination in dengue virus

Edward C. Holmes, Michael Worobey, Andrew Rambaut

Research output: Contribution to journalArticle

268 Citations (Scopus)

Abstract

A split decomposition analysis of dengue (DEN) virus gene sequences revealed extensive networked evolution, indicative of recombination, among DEN-1 strains but not within serotypes DEN-2, DEN-3, or DEN-4. Within DEN-1, two viruses sampled from South America in the last 10 years were identified as recombinants. To map the breakpoints and test their statistical support, we developed a novel maximum likelihood method. In both recombinants, the breakpoints were found to be in similar positions, within the fusion peptide of the envelope protein, demonstrating that a single recombination event occurred prior to the divergence of these two strains. This is the first report of recombination in natural populations of dengue virus.

Original languageEnglish (US)
Pages (from-to)405-409
Number of pages5
JournalMolecular Biology and Evolution
Volume16
Issue number3
StatePublished - Mar 1999
Externally publishedYes

Fingerprint

Dengue virus
Dengue Virus
dengue
Dengue
Viruses
Genetic Recombination
recombination
virus
phylogenetics
phylogeny
decomposition analysis
Statistical tests
peptide
Maximum likelihood
Fusion reactions
Genes
divergence
South America
Decomposition
Peptides

Keywords

  • Dengue virus
  • Maximum likelihood
  • Networks
  • Phylogeny
  • Recombination
  • Split decomposition

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Genetics(clinical)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Ecology, Evolution, Behavior and Systematics
  • Agricultural and Biological Sciences (miscellaneous)
  • Molecular Biology

Cite this

Phylogenetic evidence for recombination in dengue virus. / Holmes, Edward C.; Worobey, Michael; Rambaut, Andrew.

In: Molecular Biology and Evolution, Vol. 16, No. 3, 03.1999, p. 405-409.

Research output: Contribution to journalArticle

Holmes, Edward C. ; Worobey, Michael ; Rambaut, Andrew. / Phylogenetic evidence for recombination in dengue virus. In: Molecular Biology and Evolution. 1999 ; Vol. 16, No. 3. pp. 405-409.
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