Physical activity and clinical and functional status in COPD

Judith Garcia-Aymerich, Ignasi Serra, Federico P. Gómez, Eva Farrero, Eva Balcells, Diego A. Rodríguez, Jordi De Batlle, Elena Gimeno, David Donaire-Gonzalez, Mauricio Orozco-Levi, Jaume Sauleda, Joaquim Gea, Robert Rodriguez-Roisin, Josep Roca, Àlvar G. Agustí, Josep M. Antó, Marta Benet, Stefano Guerra, Àngel Gayete, Ivan VollmerJoan Albert Barbera, Carles Paré, Xavier Freixa, Karina Portillo, Jaume Ferrer, Jordi Andreu, Esther Pallissa, Esther Rodríguez, Pere Casan, Rosa Güell, Ana Giménez, Eduard Monsó, Alicia Marín, Josep Morera, Joan Escarrabill, Antoni Ferrer, Bernat Togores, Juan Bautista Gáldiz, Lorena López, José Belda

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Background: The mechanisms underlying the benefits of regular physical activity in the evolution of COPD have not been established. Our objective was to assess the relationship between regular physical activity and the clinical and functional characteristics of COPD. Methods: Three hundred forty-one patients were hospitalized for the first time because of a COPD exacerbation in nine teaching hospitals in Spain. COPD diagnosis was confirmed by spirometry under stable conditions. Physical activity before the first COPD hospitalization was measured using the Yale questionnaire. The following outcome variables were studied under stable conditions: dyspnea, nutritional status, complete lung function tests, respiratory and peripheral muscle strength, bronchial colonization, and systemic inflammation. Results: The mean age was 68 years (SD, 9 years), 93% were men, 43% were current smokers, and the mean postbronchodilator FEV1 was 52% predicted (SD, 16% predicted). Multivariate linear regression models were built separately for each outcome variable and adjusted for potential confounders (including remaining outcomes if appropriate). When patients with the lowest quartile of physical activity were compared to patients in the other quartiles, physical activity was associated with significantly higher diffusing capacity of the lung for carbon monoxide (DLCO) [change in the second, third, and fourth quartiles of physical activity, compared with first quartile (+ 6%, + 6%, and + 9% predicted, respectively; p = 0.012 [for trend])], expiratory muscle strength (maximal expiratory pressure [PEmax]) [+ 7%, + 5%, and + 9% predicted, respectively; p = 0.081], 6-min walking distance (6MWD) [+ 40, + 41, and + 45 m, respectively; p = 0.006 (for trend)], and maximal oxygen uptake (V̇O2peak) [+ 55, + 185, and + 81 mL/min, respectively; p = 0.110 (for trend)]. Similarly, physical activity reduced the risk of having high levels of circulating tumor necrosis factor α (odds ratio, 0.78, 0.61, and 0.36, respectively; p = 0.011) and C-reactive protein (0.70, 0.51, and 0.52, respectively; p = 0.036) in multivariate logistic regression. Conclusions: More physically active COPD patients show better functional status in terms of DLCO, PEmax, 6MWD, V̇O2peak, and systemic inflammation.

Original languageEnglish (US)
Pages (from-to)62-70
Number of pages9
JournalCHEST
Volume136
Issue number1
DOIs
StatePublished - Jul 1 2009
Externally publishedYes

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Chronic Obstructive Pulmonary Disease
Exercise
Muscle Strength
Walking
Linear Models
Inflammation
Lung Volume Measurements
Respiratory Muscles
Spirometry
Respiratory Function Tests
Carbon Monoxide
Nutritional Status
Teaching Hospitals
Dyspnea
C-Reactive Protein
Spain
Hospitalization
Tumor Necrosis Factor-alpha
Logistic Models
Odds Ratio

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Garcia-Aymerich, J., Serra, I., Gómez, F. P., Farrero, E., Balcells, E., Rodríguez, D. A., ... Belda, J. (2009). Physical activity and clinical and functional status in COPD. CHEST, 136(1), 62-70. https://doi.org/10.1378/chest.08-2532

Physical activity and clinical and functional status in COPD. / Garcia-Aymerich, Judith; Serra, Ignasi; Gómez, Federico P.; Farrero, Eva; Balcells, Eva; Rodríguez, Diego A.; De Batlle, Jordi; Gimeno, Elena; Donaire-Gonzalez, David; Orozco-Levi, Mauricio; Sauleda, Jaume; Gea, Joaquim; Rodriguez-Roisin, Robert; Roca, Josep; Agustí, Àlvar G.; Antó, Josep M.; Benet, Marta; Guerra, Stefano; Gayete, Àngel; Vollmer, Ivan; Barbera, Joan Albert; Paré, Carles; Freixa, Xavier; Portillo, Karina; Ferrer, Jaume; Andreu, Jordi; Pallissa, Esther; Rodríguez, Esther; Casan, Pere; Güell, Rosa; Giménez, Ana; Monsó, Eduard; Marín, Alicia; Morera, Josep; Escarrabill, Joan; Ferrer, Antoni; Togores, Bernat; Gáldiz, Juan Bautista; López, Lorena; Belda, José.

In: CHEST, Vol. 136, No. 1, 01.07.2009, p. 62-70.

Research output: Contribution to journalArticle

Garcia-Aymerich, J, Serra, I, Gómez, FP, Farrero, E, Balcells, E, Rodríguez, DA, De Batlle, J, Gimeno, E, Donaire-Gonzalez, D, Orozco-Levi, M, Sauleda, J, Gea, J, Rodriguez-Roisin, R, Roca, J, Agustí, ÀG, Antó, JM, Benet, M, Guerra, S, Gayete, À, Vollmer, I, Barbera, JA, Paré, C, Freixa, X, Portillo, K, Ferrer, J, Andreu, J, Pallissa, E, Rodríguez, E, Casan, P, Güell, R, Giménez, A, Monsó, E, Marín, A, Morera, J, Escarrabill, J, Ferrer, A, Togores, B, Gáldiz, JB, López, L & Belda, J 2009, 'Physical activity and clinical and functional status in COPD', CHEST, vol. 136, no. 1, pp. 62-70. https://doi.org/10.1378/chest.08-2532
Garcia-Aymerich J, Serra I, Gómez FP, Farrero E, Balcells E, Rodríguez DA et al. Physical activity and clinical and functional status in COPD. CHEST. 2009 Jul 1;136(1):62-70. https://doi.org/10.1378/chest.08-2532
Garcia-Aymerich, Judith ; Serra, Ignasi ; Gómez, Federico P. ; Farrero, Eva ; Balcells, Eva ; Rodríguez, Diego A. ; De Batlle, Jordi ; Gimeno, Elena ; Donaire-Gonzalez, David ; Orozco-Levi, Mauricio ; Sauleda, Jaume ; Gea, Joaquim ; Rodriguez-Roisin, Robert ; Roca, Josep ; Agustí, Àlvar G. ; Antó, Josep M. ; Benet, Marta ; Guerra, Stefano ; Gayete, Àngel ; Vollmer, Ivan ; Barbera, Joan Albert ; Paré, Carles ; Freixa, Xavier ; Portillo, Karina ; Ferrer, Jaume ; Andreu, Jordi ; Pallissa, Esther ; Rodríguez, Esther ; Casan, Pere ; Güell, Rosa ; Giménez, Ana ; Monsó, Eduard ; Marín, Alicia ; Morera, Josep ; Escarrabill, Joan ; Ferrer, Antoni ; Togores, Bernat ; Gáldiz, Juan Bautista ; López, Lorena ; Belda, José. / Physical activity and clinical and functional status in COPD. In: CHEST. 2009 ; Vol. 136, No. 1. pp. 62-70.
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abstract = "Background: The mechanisms underlying the benefits of regular physical activity in the evolution of COPD have not been established. Our objective was to assess the relationship between regular physical activity and the clinical and functional characteristics of COPD. Methods: Three hundred forty-one patients were hospitalized for the first time because of a COPD exacerbation in nine teaching hospitals in Spain. COPD diagnosis was confirmed by spirometry under stable conditions. Physical activity before the first COPD hospitalization was measured using the Yale questionnaire. The following outcome variables were studied under stable conditions: dyspnea, nutritional status, complete lung function tests, respiratory and peripheral muscle strength, bronchial colonization, and systemic inflammation. Results: The mean age was 68 years (SD, 9 years), 93{\%} were men, 43{\%} were current smokers, and the mean postbronchodilator FEV1 was 52{\%} predicted (SD, 16{\%} predicted). Multivariate linear regression models were built separately for each outcome variable and adjusted for potential confounders (including remaining outcomes if appropriate). When patients with the lowest quartile of physical activity were compared to patients in the other quartiles, physical activity was associated with significantly higher diffusing capacity of the lung for carbon monoxide (DLCO) [change in the second, third, and fourth quartiles of physical activity, compared with first quartile (+ 6{\%}, + 6{\%}, and + 9{\%} predicted, respectively; p = 0.012 [for trend])], expiratory muscle strength (maximal expiratory pressure [PEmax]) [+ 7{\%}, + 5{\%}, and + 9{\%} predicted, respectively; p = 0.081], 6-min walking distance (6MWD) [+ 40, + 41, and + 45 m, respectively; p = 0.006 (for trend)], and maximal oxygen uptake (V̇O2peak) [+ 55, + 185, and + 81 mL/min, respectively; p = 0.110 (for trend)]. Similarly, physical activity reduced the risk of having high levels of circulating tumor necrosis factor α (odds ratio, 0.78, 0.61, and 0.36, respectively; p = 0.011) and C-reactive protein (0.70, 0.51, and 0.52, respectively; p = 0.036) in multivariate logistic regression. Conclusions: More physically active COPD patients show better functional status in terms of DLCO, PEmax, 6MWD, V̇O2peak, and systemic inflammation.",
author = "Judith Garcia-Aymerich and Ignasi Serra and G{\'o}mez, {Federico P.} and Eva Farrero and Eva Balcells and Rodr{\'i}guez, {Diego A.} and {De Batlle}, Jordi and Elena Gimeno and David Donaire-Gonzalez and Mauricio Orozco-Levi and Jaume Sauleda and Joaquim Gea and Robert Rodriguez-Roisin and Josep Roca and Agust{\'i}, {{\`A}lvar G.} and Ant{\'o}, {Josep M.} and Marta Benet and Stefano Guerra and {\`A}ngel Gayete and Ivan Vollmer and Barbera, {Joan Albert} and Carles Par{\'e} and Xavier Freixa and Karina Portillo and Jaume Ferrer and Jordi Andreu and Esther Pallissa and Esther Rodr{\'i}guez and Pere Casan and Rosa G{\"u}ell and Ana Gim{\'e}nez and Eduard Mons{\'o} and Alicia Mar{\'i}n and Josep Morera and Joan Escarrabill and Antoni Ferrer and Bernat Togores and G{\'a}ldiz, {Juan Bautista} and Lorena L{\'o}pez and Jos{\'e} Belda",
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doi = "10.1378/chest.08-2532",
language = "English (US)",
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TY - JOUR

T1 - Physical activity and clinical and functional status in COPD

AU - Garcia-Aymerich, Judith

AU - Serra, Ignasi

AU - Gómez, Federico P.

AU - Farrero, Eva

AU - Balcells, Eva

AU - Rodríguez, Diego A.

AU - De Batlle, Jordi

AU - Gimeno, Elena

AU - Donaire-Gonzalez, David

AU - Orozco-Levi, Mauricio

AU - Sauleda, Jaume

AU - Gea, Joaquim

AU - Rodriguez-Roisin, Robert

AU - Roca, Josep

AU - Agustí, Àlvar G.

AU - Antó, Josep M.

AU - Benet, Marta

AU - Guerra, Stefano

AU - Gayete, Àngel

AU - Vollmer, Ivan

AU - Barbera, Joan Albert

AU - Paré, Carles

AU - Freixa, Xavier

AU - Portillo, Karina

AU - Ferrer, Jaume

AU - Andreu, Jordi

AU - Pallissa, Esther

AU - Rodríguez, Esther

AU - Casan, Pere

AU - Güell, Rosa

AU - Giménez, Ana

AU - Monsó, Eduard

AU - Marín, Alicia

AU - Morera, Josep

AU - Escarrabill, Joan

AU - Ferrer, Antoni

AU - Togores, Bernat

AU - Gáldiz, Juan Bautista

AU - López, Lorena

AU - Belda, José

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Background: The mechanisms underlying the benefits of regular physical activity in the evolution of COPD have not been established. Our objective was to assess the relationship between regular physical activity and the clinical and functional characteristics of COPD. Methods: Three hundred forty-one patients were hospitalized for the first time because of a COPD exacerbation in nine teaching hospitals in Spain. COPD diagnosis was confirmed by spirometry under stable conditions. Physical activity before the first COPD hospitalization was measured using the Yale questionnaire. The following outcome variables were studied under stable conditions: dyspnea, nutritional status, complete lung function tests, respiratory and peripheral muscle strength, bronchial colonization, and systemic inflammation. Results: The mean age was 68 years (SD, 9 years), 93% were men, 43% were current smokers, and the mean postbronchodilator FEV1 was 52% predicted (SD, 16% predicted). Multivariate linear regression models were built separately for each outcome variable and adjusted for potential confounders (including remaining outcomes if appropriate). When patients with the lowest quartile of physical activity were compared to patients in the other quartiles, physical activity was associated with significantly higher diffusing capacity of the lung for carbon monoxide (DLCO) [change in the second, third, and fourth quartiles of physical activity, compared with first quartile (+ 6%, + 6%, and + 9% predicted, respectively; p = 0.012 [for trend])], expiratory muscle strength (maximal expiratory pressure [PEmax]) [+ 7%, + 5%, and + 9% predicted, respectively; p = 0.081], 6-min walking distance (6MWD) [+ 40, + 41, and + 45 m, respectively; p = 0.006 (for trend)], and maximal oxygen uptake (V̇O2peak) [+ 55, + 185, and + 81 mL/min, respectively; p = 0.110 (for trend)]. Similarly, physical activity reduced the risk of having high levels of circulating tumor necrosis factor α (odds ratio, 0.78, 0.61, and 0.36, respectively; p = 0.011) and C-reactive protein (0.70, 0.51, and 0.52, respectively; p = 0.036) in multivariate logistic regression. Conclusions: More physically active COPD patients show better functional status in terms of DLCO, PEmax, 6MWD, V̇O2peak, and systemic inflammation.

AB - Background: The mechanisms underlying the benefits of regular physical activity in the evolution of COPD have not been established. Our objective was to assess the relationship between regular physical activity and the clinical and functional characteristics of COPD. Methods: Three hundred forty-one patients were hospitalized for the first time because of a COPD exacerbation in nine teaching hospitals in Spain. COPD diagnosis was confirmed by spirometry under stable conditions. Physical activity before the first COPD hospitalization was measured using the Yale questionnaire. The following outcome variables were studied under stable conditions: dyspnea, nutritional status, complete lung function tests, respiratory and peripheral muscle strength, bronchial colonization, and systemic inflammation. Results: The mean age was 68 years (SD, 9 years), 93% were men, 43% were current smokers, and the mean postbronchodilator FEV1 was 52% predicted (SD, 16% predicted). Multivariate linear regression models were built separately for each outcome variable and adjusted for potential confounders (including remaining outcomes if appropriate). When patients with the lowest quartile of physical activity were compared to patients in the other quartiles, physical activity was associated with significantly higher diffusing capacity of the lung for carbon monoxide (DLCO) [change in the second, third, and fourth quartiles of physical activity, compared with first quartile (+ 6%, + 6%, and + 9% predicted, respectively; p = 0.012 [for trend])], expiratory muscle strength (maximal expiratory pressure [PEmax]) [+ 7%, + 5%, and + 9% predicted, respectively; p = 0.081], 6-min walking distance (6MWD) [+ 40, + 41, and + 45 m, respectively; p = 0.006 (for trend)], and maximal oxygen uptake (V̇O2peak) [+ 55, + 185, and + 81 mL/min, respectively; p = 0.110 (for trend)]. Similarly, physical activity reduced the risk of having high levels of circulating tumor necrosis factor α (odds ratio, 0.78, 0.61, and 0.36, respectively; p = 0.011) and C-reactive protein (0.70, 0.51, and 0.52, respectively; p = 0.036) in multivariate logistic regression. Conclusions: More physically active COPD patients show better functional status in terms of DLCO, PEmax, 6MWD, V̇O2peak, and systemic inflammation.

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