Physical activity and survival in postmenopausal women with breast cancer: Results from the women's health initiative

Melinda L. Irwin, Anne McTiernan, JoAnn E. Manson, Cynthia Thomson, Barbara Sternfeld, Marcia L. Stefanick, Jean Wactawski-Wende, Lynette Craft, Dorothy Lane, Lisa W. Martin, Rowan Chlebowski

Research output: Contribution to journalArticle

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Abstract

Although studies have shown that physically active breast cancer survivors have lower all-cause mortality, the association between change in physical activity from before to after diagnosis and mortality is not clear. We examined associations among pre- and postdiagnosis physical activity, change in pre- to postdiagnosis physical activity, and all-cause and breast cancer - specific mortality in postmenopausal women. A longitudinal study of 4,643 women diagnosed with invasive breast cancer after entry into the Women's Health Initiative study of postmenopausal women. Physical activity from recreation and walking was determined at baseline (prediagnosis) and after diagnosis (assessed at the 3 or 6 years post-baseline visit). Women participating in 9 MET-h/wk or more (∼3 h/wk of fast walking) of physical activity before diagnosis had a lower all-cause mortality (HR = 0.61; 95% CI, 0.44-0.87; P = 0.01) compared with inactive women in multivariable adjusted analyses. Women participating in ≥9 or more MET-h/wk of physical activity after diagnosis had lower breast cancer mortality (HR = 0.61; 95% CI, 0.35-0.99; P = 0.049) and lower all-cause mortality (HR = 0.54; 95% CI, 0.38-0.79; P < 0.01). Women who increased or maintained physical activity of 9 or more MET-h/wk after diagnosis had lower all-cause mortality (HR = 0.67; 95% CI, 0.46-0.96) even if they were inactive before diagnosis. High levels of physical activity may improve survival in postmenopausal women with breast cancer, even among those reporting low physical activity prior to diagnosis. Women diagnosed with breast cancer should be encouraged to initiate and maintain a program of physical activity.

Original languageEnglish (US)
Pages (from-to)522-529
Number of pages8
JournalCancer Prevention Research
Volume4
Issue number4
DOIs
StatePublished - Apr 2011

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Women's Health
Exercise
Breast Neoplasms
Survival
Mortality
Walking
Recreation
Longitudinal Studies
Survivors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Physical activity and survival in postmenopausal women with breast cancer : Results from the women's health initiative. / Irwin, Melinda L.; McTiernan, Anne; Manson, JoAnn E.; Thomson, Cynthia; Sternfeld, Barbara; Stefanick, Marcia L.; Wactawski-Wende, Jean; Craft, Lynette; Lane, Dorothy; Martin, Lisa W.; Chlebowski, Rowan.

In: Cancer Prevention Research, Vol. 4, No. 4, 04.2011, p. 522-529.

Research output: Contribution to journalArticle

Irwin, ML, McTiernan, A, Manson, JE, Thomson, C, Sternfeld, B, Stefanick, ML, Wactawski-Wende, J, Craft, L, Lane, D, Martin, LW & Chlebowski, R 2011, 'Physical activity and survival in postmenopausal women with breast cancer: Results from the women's health initiative', Cancer Prevention Research, vol. 4, no. 4, pp. 522-529. https://doi.org/10.1158/1940-6207.CAPR-10-0295
Irwin, Melinda L. ; McTiernan, Anne ; Manson, JoAnn E. ; Thomson, Cynthia ; Sternfeld, Barbara ; Stefanick, Marcia L. ; Wactawski-Wende, Jean ; Craft, Lynette ; Lane, Dorothy ; Martin, Lisa W. ; Chlebowski, Rowan. / Physical activity and survival in postmenopausal women with breast cancer : Results from the women's health initiative. In: Cancer Prevention Research. 2011 ; Vol. 4, No. 4. pp. 522-529.
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