Physical activity in older subjects is associated with increased coronary vasodilation: The ADVANCE study

Patricia K. Nguyen, Masahiro Terashima, Joan M. Fair, Ann Varady, Ruth E Taylor-Piliae, Carlos Iribarren, Alan S. Go, William L. Haskell, Mark A. Hlatky, Stephen P. Fortmann, Michael V. McConnell

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives: We investigated the association between physical activity and coronary vasodilation to nitroglycerin (NTG) in the ADVANCE (Atherosclerotic Disease, Vascular Function, and Genetic Epidemiology) cohort of older healthy subjects. Background: Physical activity may exert its beneficial effects by augmenting coronary responsiveness to nitric oxide. The relationship between physical activity and coronary vasodilatory response to NTG, an exogenous nitric oxide donor, has not been studied in a community-based population with typical activity levels. Methods: In 212 older adults (ages 60 to 72 years) without cardiovascular disease, we measured the coronary vasodilatory response to NTG using magnetic resonance angiography and physical activity using the Stanford Seven-Day Physical Activity Recall Questionnaire. The primary predictor measure was total physical activity (kcal/kg/day). The primary outcome measure was coronary vasodilatory response (percent increase of cross-sectional area post-NTG). Results: Coronary vasodilation was 27.6% in more active subjects (>35 kcal/kg/day, e.g., 1 h of walking per day) compared to 18.9% in less active subjects (p = 0.03). Regression analysis showed a significant positive correlation between coronary vasodilation and physical activity (p = 0.003), with a slope (beta) of 1.2% per kcal/kg/day. This finding remained significant after adjustment for cardiac risk factors, coronary calcium, the use of vasoactive or statin medications, and analysis of physical activity by quintiles (p < 0.05). Coronary vasodilation was also associated with physical activity intensity (p = 0.03). Conclusions: In an asymptomatic, community-based cohort of older adults, increased coronary vasodilatory response was independently associated with greater physical activity, supporting the benefits of exercise on the order of 1 h of walking per day.

Original languageEnglish (US)
Pages (from-to)622-629
Number of pages8
JournalJACC: Cardiovascular Imaging
Volume4
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

Fingerprint

Molecular Epidemiology
Vascular Diseases
Vasodilation
Exercise
Nitroglycerin
Walking
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Nitric Oxide Donors
Magnetic Resonance Angiography
Healthy Volunteers
Nitric Oxide
Cardiovascular Diseases
Regression Analysis
Outcome Assessment (Health Care)
Calcium

Keywords

  • coronary arteries
  • magnetic resonance imaging
  • nitroglycerin
  • vasodilation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Physical activity in older subjects is associated with increased coronary vasodilation : The ADVANCE study. / Nguyen, Patricia K.; Terashima, Masahiro; Fair, Joan M.; Varady, Ann; Taylor-Piliae, Ruth E; Iribarren, Carlos; Go, Alan S.; Haskell, William L.; Hlatky, Mark A.; Fortmann, Stephen P.; McConnell, Michael V.

In: JACC: Cardiovascular Imaging, Vol. 4, No. 6, 06.2011, p. 622-629.

Research output: Contribution to journalArticle

Nguyen, PK, Terashima, M, Fair, JM, Varady, A, Taylor-Piliae, RE, Iribarren, C, Go, AS, Haskell, WL, Hlatky, MA, Fortmann, SP & McConnell, MV 2011, 'Physical activity in older subjects is associated with increased coronary vasodilation: The ADVANCE study', JACC: Cardiovascular Imaging, vol. 4, no. 6, pp. 622-629. https://doi.org/10.1016/j.jcmg.2011.05.001
Nguyen, Patricia K. ; Terashima, Masahiro ; Fair, Joan M. ; Varady, Ann ; Taylor-Piliae, Ruth E ; Iribarren, Carlos ; Go, Alan S. ; Haskell, William L. ; Hlatky, Mark A. ; Fortmann, Stephen P. ; McConnell, Michael V. / Physical activity in older subjects is associated with increased coronary vasodilation : The ADVANCE study. In: JACC: Cardiovascular Imaging. 2011 ; Vol. 4, No. 6. pp. 622-629.
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abstract = "Objectives: We investigated the association between physical activity and coronary vasodilation to nitroglycerin (NTG) in the ADVANCE (Atherosclerotic Disease, Vascular Function, and Genetic Epidemiology) cohort of older healthy subjects. Background: Physical activity may exert its beneficial effects by augmenting coronary responsiveness to nitric oxide. The relationship between physical activity and coronary vasodilatory response to NTG, an exogenous nitric oxide donor, has not been studied in a community-based population with typical activity levels. Methods: In 212 older adults (ages 60 to 72 years) without cardiovascular disease, we measured the coronary vasodilatory response to NTG using magnetic resonance angiography and physical activity using the Stanford Seven-Day Physical Activity Recall Questionnaire. The primary predictor measure was total physical activity (kcal/kg/day). The primary outcome measure was coronary vasodilatory response (percent increase of cross-sectional area post-NTG). Results: Coronary vasodilation was 27.6{\%} in more active subjects (>35 kcal/kg/day, e.g., 1 h of walking per day) compared to 18.9{\%} in less active subjects (p = 0.03). Regression analysis showed a significant positive correlation between coronary vasodilation and physical activity (p = 0.003), with a slope (beta) of 1.2{\%} per kcal/kg/day. This finding remained significant after adjustment for cardiac risk factors, coronary calcium, the use of vasoactive or statin medications, and analysis of physical activity by quintiles (p < 0.05). Coronary vasodilation was also associated with physical activity intensity (p = 0.03). Conclusions: In an asymptomatic, community-based cohort of older adults, increased coronary vasodilatory response was independently associated with greater physical activity, supporting the benefits of exercise on the order of 1 h of walking per day.",
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T1 - Physical activity in older subjects is associated with increased coronary vasodilation

T2 - The ADVANCE study

AU - Nguyen, Patricia K.

AU - Terashima, Masahiro

AU - Fair, Joan M.

AU - Varady, Ann

AU - Taylor-Piliae, Ruth E

AU - Iribarren, Carlos

AU - Go, Alan S.

AU - Haskell, William L.

AU - Hlatky, Mark A.

AU - Fortmann, Stephen P.

AU - McConnell, Michael V.

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N2 - Objectives: We investigated the association between physical activity and coronary vasodilation to nitroglycerin (NTG) in the ADVANCE (Atherosclerotic Disease, Vascular Function, and Genetic Epidemiology) cohort of older healthy subjects. Background: Physical activity may exert its beneficial effects by augmenting coronary responsiveness to nitric oxide. The relationship between physical activity and coronary vasodilatory response to NTG, an exogenous nitric oxide donor, has not been studied in a community-based population with typical activity levels. Methods: In 212 older adults (ages 60 to 72 years) without cardiovascular disease, we measured the coronary vasodilatory response to NTG using magnetic resonance angiography and physical activity using the Stanford Seven-Day Physical Activity Recall Questionnaire. The primary predictor measure was total physical activity (kcal/kg/day). The primary outcome measure was coronary vasodilatory response (percent increase of cross-sectional area post-NTG). Results: Coronary vasodilation was 27.6% in more active subjects (>35 kcal/kg/day, e.g., 1 h of walking per day) compared to 18.9% in less active subjects (p = 0.03). Regression analysis showed a significant positive correlation between coronary vasodilation and physical activity (p = 0.003), with a slope (beta) of 1.2% per kcal/kg/day. This finding remained significant after adjustment for cardiac risk factors, coronary calcium, the use of vasoactive or statin medications, and analysis of physical activity by quintiles (p < 0.05). Coronary vasodilation was also associated with physical activity intensity (p = 0.03). Conclusions: In an asymptomatic, community-based cohort of older adults, increased coronary vasodilatory response was independently associated with greater physical activity, supporting the benefits of exercise on the order of 1 h of walking per day.

AB - Objectives: We investigated the association between physical activity and coronary vasodilation to nitroglycerin (NTG) in the ADVANCE (Atherosclerotic Disease, Vascular Function, and Genetic Epidemiology) cohort of older healthy subjects. Background: Physical activity may exert its beneficial effects by augmenting coronary responsiveness to nitric oxide. The relationship between physical activity and coronary vasodilatory response to NTG, an exogenous nitric oxide donor, has not been studied in a community-based population with typical activity levels. Methods: In 212 older adults (ages 60 to 72 years) without cardiovascular disease, we measured the coronary vasodilatory response to NTG using magnetic resonance angiography and physical activity using the Stanford Seven-Day Physical Activity Recall Questionnaire. The primary predictor measure was total physical activity (kcal/kg/day). The primary outcome measure was coronary vasodilatory response (percent increase of cross-sectional area post-NTG). Results: Coronary vasodilation was 27.6% in more active subjects (>35 kcal/kg/day, e.g., 1 h of walking per day) compared to 18.9% in less active subjects (p = 0.03). Regression analysis showed a significant positive correlation between coronary vasodilation and physical activity (p = 0.003), with a slope (beta) of 1.2% per kcal/kg/day. This finding remained significant after adjustment for cardiac risk factors, coronary calcium, the use of vasoactive or statin medications, and analysis of physical activity by quintiles (p < 0.05). Coronary vasodilation was also associated with physical activity intensity (p = 0.03). Conclusions: In an asymptomatic, community-based cohort of older adults, increased coronary vasodilatory response was independently associated with greater physical activity, supporting the benefits of exercise on the order of 1 h of walking per day.

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