Physical characterization of component particles included in dry powder inhalers. II. Dynamic characteristics

Anthony J. Hickey, Heidi - Mansour, Martin J. Telko, Zhen Xu, Hugh D C Smyth, Tako Mulder, Richard Mclean, John Langridge, Dimitris Papadopoulos

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Characteristics of particles included in dry powder inhalers is extended from our previous report (in this journal) to include properties related to their dynamic performance. The performance of dry powder aerosols for pulmonary delivery is known to depend on fluidization and dispersion which reflects particle interactions in static powder beds. Since the solid state, surface/interfacial chemistry and static bulk properties were assessed previously, it remains to describe dynamic performance with a view to interpreting the integrated database. These studies result in complex data matrices from which correlations between specific properties and performance may be deduced. Lactose particles were characterized in terms of their dynamic flow, powder and aerosol electrostatics, and aerodynamic performance with respect to albuterol aerosol dispersion. There were clear correlations between flow properties and aerosol dispersion that would allow selection of lactose particles for formulation. Moreover, these properties can be related to data reported earlier on the morphological and surface properties of the carrier lactose particles. The proposed series of analytical approaches to the evaluation of powders for inclusion in aerosol products has merit and may be the basis for screening and ultimately predicting particle performance with a view to formulation optimization.

Original languageEnglish (US)
Pages (from-to)1302-1319
Number of pages18
JournalJournal of Pharmaceutical Sciences
Volume96
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

Fingerprint

Dry Powder Inhalers
Aerosols
Powders
Lactose
Surface chemistry
Surface Properties
Particle interactions
Albuterol
Fluidization
Static Electricity
Surface properties
Electrostatics
Aerodynamics
Screening
Databases
Lung

Keywords

  • Aerosols
  • Microparticles
  • Physical characterization
  • Physicochemical
  • Powder technology
  • Pulmonary
  • Pulmonary drug delivery
  • Solid state
  • Static charge
  • Surface chemistry

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

Cite this

Physical characterization of component particles included in dry powder inhalers. II. Dynamic characteristics. / Hickey, Anthony J.; Mansour, Heidi -; Telko, Martin J.; Xu, Zhen; Smyth, Hugh D C; Mulder, Tako; Mclean, Richard; Langridge, John; Papadopoulos, Dimitris.

In: Journal of Pharmaceutical Sciences, Vol. 96, No. 5, 05.2007, p. 1302-1319.

Research output: Contribution to journalArticle

Hickey, AJ, Mansour, H, Telko, MJ, Xu, Z, Smyth, HDC, Mulder, T, Mclean, R, Langridge, J & Papadopoulos, D 2007, 'Physical characterization of component particles included in dry powder inhalers. II. Dynamic characteristics', Journal of Pharmaceutical Sciences, vol. 96, no. 5, pp. 1302-1319. https://doi.org/10.1002/jps.20943
Hickey, Anthony J. ; Mansour, Heidi - ; Telko, Martin J. ; Xu, Zhen ; Smyth, Hugh D C ; Mulder, Tako ; Mclean, Richard ; Langridge, John ; Papadopoulos, Dimitris. / Physical characterization of component particles included in dry powder inhalers. II. Dynamic characteristics. In: Journal of Pharmaceutical Sciences. 2007 ; Vol. 96, No. 5. pp. 1302-1319.
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