Physical characterization of component particles included in dry powder inhalers. I. Strategy review and static characteristics

Anthony J. Hickey, Heidi M. Mansour, Martin J. Telko, Zhen Xu, Hugh D.C. Smyth, Tako Mulder, Richard Mclean, John Langridge, Dimitris Papadopoulos

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

The performance of dry powder aerosols for the delivery of drugs to the lungs has been studied extensively in the last decade. The focus for different research groups has been on aspects of the powder formulation, which relate to solid state, surface and interfacial chemistry, bulk properties (static and dynamic) and measures of performance. The nature of studies in this field, tend to be complex and correlations between specific properties and performance seem to be rare. Consequently, the adoption of formulation approaches that on a predictive basis lead to desirable performance has been an elusive goal but one that many agree is worth striving towards. The purpose of this paper is to initiate a discussion of the use of a variety of techniques to elucidate dry particle behavior that might guide the data collection process. If the many researchers in this field can agree on this, or an alternative, guide then a database can be constructed that would allow predictive models to be developed. This is the first of two papers that discuss static and dynamic methods of characterizing dry powder inhaler formulations.

Original languageEnglish (US)
Pages (from-to)1282-1301
Number of pages20
JournalJournal of pharmaceutical sciences
Volume96
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

Keywords

  • Aerosols
  • Formulation
  • Physical characterization
  • Physicochemical
  • Preformulation
  • Pulmonary
  • Pulmonary drug delivery
  • Solid state
  • Surface chemistry
  • Thermodynamics

ASJC Scopus subject areas

  • Pharmaceutical Science

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    Hickey, A. J., Mansour, H. M., Telko, M. J., Xu, Z., Smyth, H. D. C., Mulder, T., Mclean, R., Langridge, J., & Papadopoulos, D. (2007). Physical characterization of component particles included in dry powder inhalers. I. Strategy review and static characteristics. Journal of pharmaceutical sciences, 96(5), 1282-1301. https://doi.org/10.1002/jps.20916