Physiology of the Malpighian tubule

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

The Malpighian tubule secretes a nearly isosmotic fluid with Na+, K+, and Cl- serving as the principal osmolytes. Considerable progress has been made in characterizing the molecular identities and biochemical properties of the apical membrane transport pathways for Na+ and K+. Transport of these cations from the cell into the tubule lumen is achieved by a vacuolar H+ ATPase that operates in parallel with a cation/H+ exchanger. A variety of diuretic peptides influence fluid secretion rates by Malpighian tubules in vitro. Many of these peptides influence electrogenic ion transport across the apical or basolateral membranes of the epithelial cells. Detailed electrophysiological studies on tubules of several species have provided insights into the contributions of constitutive and regulated electrolyte transport pathways to the process of fluid and electrolyte secretion. This review focuses on some essential features of several models that describe membrane and transepithelial electrolyte transport in the Malpighian tubule.

Original languageEnglish (US)
Pages (from-to)493-510
Number of pages18
JournalAnnual Review of Entomology
Volume40
Issue number1
StatePublished - 1995
Externally publishedYes

Fingerprint

Malpighian tubules
electrolyte
electrolytes
physiology
membrane
secretion
peptide
fluid
cations
cation
peptides
H-transporting ATP synthase
diuretics
ion transport
epithelial cells
ion
fluids
cells

Keywords

  • Diuretic peptide
  • Epithelial transport
  • Fluid secretion
  • Membrane transport
  • Vacuolar proton pump

ASJC Scopus subject areas

  • Insect Science

Cite this

Physiology of the Malpighian tubule. / Pannabecker, Thomas L.

In: Annual Review of Entomology, Vol. 40, No. 1, 1995, p. 493-510.

Research output: Contribution to journalArticle

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