Phytochemical investigation of Adenium obesum forskal (Apocynaceae)

Isolation and identification of cytotoxic agents

J. J. Hoffmann, Jack R Cole

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

An ethanol extract of Adenium obesum exhibited cytotoxic activity against the human epidermoid carcinoma of the nasopharynx test system. Constituents in the active extract were identified as the cardenolides somalin, hongheloside A, 16 acetylstrospeside, and honghelin and the flavonol 3,3' bis(O methyl)quercetin. Their identities were proven by IR, UV, proton magnetic resonance, and mass spectrometry; elemental analyses; preparation of derivatives; and melting point determinations. An inactive triterpene, dihydroifflaionic acid, and an inactive flavonol, 3 O methylkaempferol, also were isolated and identified.

Original languageEnglish (US)
Pages (from-to)1336-1338
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume66
Issue number9
StatePublished - 1977

Fingerprint

Apocynaceae
Cytotoxins
Phytochemicals
Cardenolides
Triterpenes
Nasopharynx
Quercetin
Human Activities
Freezing
Mass spectrometry
Melting point
Protons
Squamous Cell Carcinoma
Mass Spectrometry
Ethanol
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Derivatives
Acids
3-hydroxyflavone

ASJC Scopus subject areas

  • Molecular Medicine
  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology

Cite this

Phytochemical investigation of Adenium obesum forskal (Apocynaceae) : Isolation and identification of cytotoxic agents. / Hoffmann, J. J.; Cole, Jack R.

In: Journal of Pharmaceutical Sciences, Vol. 66, No. 9, 1977, p. 1336-1338.

Research output: Contribution to journalArticle

@article{f4a67ef9deb24519b2f0cc8af7b8628f,
title = "Phytochemical investigation of Adenium obesum forskal (Apocynaceae): Isolation and identification of cytotoxic agents",
abstract = "An ethanol extract of Adenium obesum exhibited cytotoxic activity against the human epidermoid carcinoma of the nasopharynx test system. Constituents in the active extract were identified as the cardenolides somalin, hongheloside A, 16 acetylstrospeside, and honghelin and the flavonol 3,3' bis(O methyl)quercetin. Their identities were proven by IR, UV, proton magnetic resonance, and mass spectrometry; elemental analyses; preparation of derivatives; and melting point determinations. An inactive triterpene, dihydroifflaionic acid, and an inactive flavonol, 3 O methylkaempferol, also were isolated and identified.",
author = "Hoffmann, {J. J.} and Cole, {Jack R}",
year = "1977",
language = "English (US)",
volume = "66",
pages = "1336--1338",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

TY - JOUR

T1 - Phytochemical investigation of Adenium obesum forskal (Apocynaceae)

T2 - Isolation and identification of cytotoxic agents

AU - Hoffmann, J. J.

AU - Cole, Jack R

PY - 1977

Y1 - 1977

N2 - An ethanol extract of Adenium obesum exhibited cytotoxic activity against the human epidermoid carcinoma of the nasopharynx test system. Constituents in the active extract were identified as the cardenolides somalin, hongheloside A, 16 acetylstrospeside, and honghelin and the flavonol 3,3' bis(O methyl)quercetin. Their identities were proven by IR, UV, proton magnetic resonance, and mass spectrometry; elemental analyses; preparation of derivatives; and melting point determinations. An inactive triterpene, dihydroifflaionic acid, and an inactive flavonol, 3 O methylkaempferol, also were isolated and identified.

AB - An ethanol extract of Adenium obesum exhibited cytotoxic activity against the human epidermoid carcinoma of the nasopharynx test system. Constituents in the active extract were identified as the cardenolides somalin, hongheloside A, 16 acetylstrospeside, and honghelin and the flavonol 3,3' bis(O methyl)quercetin. Their identities were proven by IR, UV, proton magnetic resonance, and mass spectrometry; elemental analyses; preparation of derivatives; and melting point determinations. An inactive triterpene, dihydroifflaionic acid, and an inactive flavonol, 3 O methylkaempferol, also were isolated and identified.

UR - http://www.scopus.com/inward/record.url?scp=0017737161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017737161&partnerID=8YFLogxK

M3 - Article

VL - 66

SP - 1336

EP - 1338

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 9

ER -