An ethanol extract of Adenium obesum exhibited cytotoxic activity against the human epidermoid carcinoma of the nasopharynx test system. Constituents in the active extract were identified as the cardenolides somalin, hongheloside A, 16‐acetylstrospeside, and honghelin and the flavonol 3,3′‐bis(O‐methyl)quercetin. Their identities were proven by IR, UV, proton magnetic resonance, and mass spectrometry; elemental analyses; preparation of derivatives; and melting‐point determinations. An inactive triterpene, dihydroifflaionic acid, and an inactive flavonol, 3‐O‐methylkaempferol, also were isolated and identified.
- Adenium obesum—ethanol extract of aboveground parts, various cardenolides and flavonol isolated and identified, evaluated for cytotoxic activity
- Cardenolides, various—isolated from ethanol extract of aboveground parts of Adenium obesum, evaluated for cytotoxic activity
- Cytotoxic activity—evaluated in various cardenolides and flavonol isolated from ethanol extract of aboveground parts of Adenium obesum
- Flavonols—3,3′‐bis(O‐methyl)quercetin isolated from ethanol extract of aboveground parts of Adenium obesum, evaluated for cytotoxic activity
ASJC Scopus subject areas
- Pharmaceutical Science