Phytochemical investigation of Adenium obesum forskal (apocynaceae): Isolation and identification of cytotoxic agents

Joseph J. Hoffmann, Jack R. Cole

Research output: Contribution to journalComment/debate

13 Scopus citations

Abstract

An ethanol extract of Adenium obesum exhibited cytotoxic activity against the human epidermoid carcinoma of the nasopharynx test system. Constituents in the active extract were identified as the cardenolides somalin, hongheloside A, 16‐acetylstrospeside, and honghelin and the flavonol 3,3′‐bis(O‐methyl)quercetin. Their identities were proven by IR, UV, proton magnetic resonance, and mass spectrometry; elemental analyses; preparation of derivatives; and melting‐point determinations. An inactive triterpene, dihydroifflaionic acid, and an inactive flavonol, 3‐O‐methylkaempferol, also were isolated and identified.

Original languageEnglish (US)
Pages (from-to)1336-1338
Number of pages3
JournalJournal of pharmaceutical sciences
Volume66
Issue number9
DOIs
StatePublished - Sep 1977

Keywords

  • Adenium obesum—ethanol extract of aboveground parts, various cardenolides and flavonol isolated and identified, evaluated for cytotoxic activity
  • Cardenolides, various—isolated from ethanol extract of aboveground parts of Adenium obesum, evaluated for cytotoxic activity
  • Cytotoxic activity—evaluated in various cardenolides and flavonol isolated from ethanol extract of aboveground parts of Adenium obesum
  • Flavonols—3,3′‐bis(O‐methyl)quercetin isolated from ethanol extract of aboveground parts of Adenium obesum, evaluated for cytotoxic activity

ASJC Scopus subject areas

  • Pharmaceutical Science

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