Pierreiones A - D, solid tumor selective pyranoisoflavones and other cytotoxic constituents from antheroporum pierrei

Song Gao, Ya Ming Xu, Frederick A. Valeriote, A. A.Leslie Gunatilaka

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Bioassay-guided fractionation of a solid tumor selective extract of the leaves and twigs of Antheroporum pierrei acquired from the U.S. National Cancer Institute extract repository afforded four new pyranoisoflavones, pierreiones A-D (1-4), together with rotenone (5), 12a-hydroxyrotenone (6), and tephrosin (7). The structures of all new compounds were determined on the basis of their spectroscopic data, and the absolute configuration of 1 was assigned with the help of 1H NMR analysis of its Mosher's ester derivatives. Compounds 1 and 5-7 accounted for the majority of the biological activity in terms of either cytotoxicity and/or selective toxicity to solid tumor cell lines. Pierreiones A (1) and B (2) demonstrated solid tumor selectivity with minimal cytotoxicity, while pierreione C (3) exhibited no activity.

Original languageEnglish (US)
Pages (from-to)852-856
Number of pages5
JournalJournal Of Natural Products
Volume74
Issue number4
DOIs
StatePublished - Apr 25 2011

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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