Pierreiones A - D, solid tumor selective pyranoisoflavones and other cytotoxic constituents from antheroporum pierrei

Song Gao, Ya Ming Xu, Frederick A. Valeriote, Leslie Gunatilaka

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Bioassay-guided fractionation of a solid tumor selective extract of the leaves and twigs of Antheroporum pierrei acquired from the U.S. National Cancer Institute extract repository afforded four new pyranoisoflavones, pierreiones A-D (1-4), together with rotenone (5), 12a-hydroxyrotenone (6), and tephrosin (7). The structures of all new compounds were determined on the basis of their spectroscopic data, and the absolute configuration of 1 was assigned with the help of 1H NMR analysis of its Mosher's ester derivatives. Compounds 1 and 5-7 accounted for the majority of the biological activity in terms of either cytotoxicity and/or selective toxicity to solid tumor cell lines. Pierreiones A (1) and B (2) demonstrated solid tumor selectivity with minimal cytotoxicity, while pierreione C (3) exhibited no activity.

Original languageEnglish (US)
Pages (from-to)852-856
Number of pages5
JournalJournal of Natural Products
Volume74
Issue number4
DOIs
StatePublished - Apr 25 2011

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Tumors
Cytotoxicity
Rotenone
National Cancer Institute (U.S.)
Tumor Cell Line
Biological Assay
Neoplasms
Esters
Bioassay
Fractionation
Bioactivity
Toxicity
Cells
Nuclear magnetic resonance
Derivatives
tephrosin
Proton Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Pierreiones A - D, solid tumor selective pyranoisoflavones and other cytotoxic constituents from antheroporum pierrei. / Gao, Song; Xu, Ya Ming; Valeriote, Frederick A.; Gunatilaka, Leslie.

In: Journal of Natural Products, Vol. 74, No. 4, 25.04.2011, p. 852-856.

Research output: Contribution to journalArticle

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