Pilot studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analog, in the treatment of congestive heart failure.

Eugene Morkin, Gregory Pennock, Peter H. Spooner, Joseph J. Bahl, Katherine Underhill Fox, Steven Goldman

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

After an initial safety study in 7 normal volunteers, a randomized double-blind comparison was made between 3,5-diiodothyropropionic acid (DITPA) and placebo in 19 patients with moderately severe congestive failure. In heart failure patients receiving the drug for 4 weeks, cardiac index was increased (p = 0.04) and systemic vascular resistance index was decreased (p = 0.02). Systolic cardiac function was unchanged but isovolumetric relaxation time was decreased significantly, suggesting improvement in diastolic function. Total serum cholesterol (p = 0.005) and triglycerides (p = 0.01) also were decreased significantly. DITPA could represent a useful new agent for treatment of congestive heart failure.

Original languageEnglish (US)
Pages (from-to)218-225
Number of pages8
JournalCardiology
Volume97
Issue number4
StatePublished - 2002

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Thyroid Hormones
Heart Failure
Vascular Resistance
Healthy Volunteers
Triglycerides
Cholesterol
Placebos
Safety
Acids
Therapeutics
Serum
Pharmaceutical Preparations
3,5-diiodothyropropionic acid

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pilot studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analog, in the treatment of congestive heart failure. / Morkin, Eugene; Pennock, Gregory; Spooner, Peter H.; Bahl, Joseph J.; Underhill Fox, Katherine; Goldman, Steven.

In: Cardiology, Vol. 97, No. 4, 2002, p. 218-225.

Research output: Contribution to journalArticle

Morkin, E, Pennock, G, Spooner, PH, Bahl, JJ, Underhill Fox, K & Goldman, S 2002, 'Pilot studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analog, in the treatment of congestive heart failure.', Cardiology, vol. 97, no. 4, pp. 218-225.
Morkin, Eugene ; Pennock, Gregory ; Spooner, Peter H. ; Bahl, Joseph J. ; Underhill Fox, Katherine ; Goldman, Steven. / Pilot studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analog, in the treatment of congestive heart failure. In: Cardiology. 2002 ; Vol. 97, No. 4. pp. 218-225.
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