Pilot studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analog, in the treatment of congestive heart failure.

Eugene Morkin, Gregory Pennock, Peter H. Spooner, Joseph J. Bahl, Katherine Underhill Fox, Steven Goldman

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

After an initial safety study in 7 normal volunteers, a randomized double-blind comparison was made between 3,5-diiodothyropropionic acid (DITPA) and placebo in 19 patients with moderately severe congestive failure. In heart failure patients receiving the drug for 4 weeks, cardiac index was increased (p = 0.04) and systemic vascular resistance index was decreased (p = 0.02). Systolic cardiac function was unchanged but isovolumetric relaxation time was decreased significantly, suggesting improvement in diastolic function. Total serum cholesterol (p = 0.005) and triglycerides (p = 0.01) also were decreased significantly. DITPA could represent a useful new agent for treatment of congestive heart failure.

Original languageEnglish (US)
Pages (from-to)218-225
Number of pages8
JournalCardiology
Volume97
Issue number4
DOIs
StatePublished - 2002

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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