Pilot study of dietary influences on mammographic density in pre- and postmenopausal Hispanic and non-Hispanic white women

Cynthia Thomson, Leslie A. Arendell, Roberta L. Bruhn, Gertraud Maskarinec, Ana Maria Lopez, Nicole C. Wright, Carlos E. Moll, Mikel Aickin, Zhao Chen

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

OBJECTIVE: The extent to which modifiable dietary factors may account for some of the variability demonstrated in mammographic density across ethnic groups is unknown. The purpose of this study was to provide pilot data describing the relationship between dietary variables and mammographic density in pre- and postmenopausal Hispanic and non-Hispanic white (NHW) women (N = 238) ranging in age from 41 to 50 years (premenopausal only) or 56 to 70 years (postmenopausal only). DESIGN: Using a cross-sectional design, computer-assisted density assessments were performed on mammograms of both breasts and averaged for analysis. The Arizona Food Frequency Questionnaire was used to estimate dietary intake. RESULTS: Study participants were well educated and overweight, with mean mammographic densities ranging from 20.25% for postmenopausal Hispanic women to 46.94% for premenopausal NHW women. Hispanic women reported higher energy intake than NHW women, but energy-adjusted intake of other nutrients was generally comparable. There was preliminary evidence of ethnic variability in diet-mammographic density associations. Among premenopausal Hispanic women, density was inversely associated with dairy, calcium, and vitamin D intakes (P ≤ 0.05 for all). Among premenopausal NHW women, lower mammographic density was associated with greater intake of vegetables (P ≤ 0.05), and higher density was associated with greater fruit intake (P ≤ 0.05). Among postmenopausal Hispanic women, for every 4.54 increase in the polyunsaturated-to-saturated fat ratio, there was a 9.0% reduction in mammograph density. CONCLUSIONS: These preliminary results suggest that a differential pattern of dietary nutrient associations with mammographic density could potentially exist among Hispanic and NHW women. These ethnic differences in diet and mammographic density associations need to be further explored in larger studies.

Original languageEnglish (US)
Pages (from-to)243-250
Number of pages8
JournalMenopause
Volume14
Issue number2
DOIs
StatePublished - Mar 2007

Fingerprint

Hispanic Americans
Energy Intake
Food
Diet
Breast Density
Computer-Aided Design
Ethnic Groups
Vitamin D
Vegetables
Fruit
Breast
Fats
Calcium

Keywords

  • Breast cancer
  • Diet
  • Mammographic density

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Pilot study of dietary influences on mammographic density in pre- and postmenopausal Hispanic and non-Hispanic white women. / Thomson, Cynthia; Arendell, Leslie A.; Bruhn, Roberta L.; Maskarinec, Gertraud; Lopez, Ana Maria; Wright, Nicole C.; Moll, Carlos E.; Aickin, Mikel; Chen, Zhao.

In: Menopause, Vol. 14, No. 2, 03.2007, p. 243-250.

Research output: Contribution to journalArticle

Thomson, Cynthia ; Arendell, Leslie A. ; Bruhn, Roberta L. ; Maskarinec, Gertraud ; Lopez, Ana Maria ; Wright, Nicole C. ; Moll, Carlos E. ; Aickin, Mikel ; Chen, Zhao. / Pilot study of dietary influences on mammographic density in pre- and postmenopausal Hispanic and non-Hispanic white women. In: Menopause. 2007 ; Vol. 14, No. 2. pp. 243-250.
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abstract = "OBJECTIVE: The extent to which modifiable dietary factors may account for some of the variability demonstrated in mammographic density across ethnic groups is unknown. The purpose of this study was to provide pilot data describing the relationship between dietary variables and mammographic density in pre- and postmenopausal Hispanic and non-Hispanic white (NHW) women (N = 238) ranging in age from 41 to 50 years (premenopausal only) or 56 to 70 years (postmenopausal only). DESIGN: Using a cross-sectional design, computer-assisted density assessments were performed on mammograms of both breasts and averaged for analysis. The Arizona Food Frequency Questionnaire was used to estimate dietary intake. RESULTS: Study participants were well educated and overweight, with mean mammographic densities ranging from 20.25{\%} for postmenopausal Hispanic women to 46.94{\%} for premenopausal NHW women. Hispanic women reported higher energy intake than NHW women, but energy-adjusted intake of other nutrients was generally comparable. There was preliminary evidence of ethnic variability in diet-mammographic density associations. Among premenopausal Hispanic women, density was inversely associated with dairy, calcium, and vitamin D intakes (P ≤ 0.05 for all). Among premenopausal NHW women, lower mammographic density was associated with greater intake of vegetables (P ≤ 0.05), and higher density was associated with greater fruit intake (P ≤ 0.05). Among postmenopausal Hispanic women, for every 4.54 increase in the polyunsaturated-to-saturated fat ratio, there was a 9.0{\%} reduction in mammograph density. CONCLUSIONS: These preliminary results suggest that a differential pattern of dietary nutrient associations with mammographic density could potentially exist among Hispanic and NHW women. These ethnic differences in diet and mammographic density associations need to be further explored in larger studies.",
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AU - Thomson, Cynthia

AU - Arendell, Leslie A.

AU - Bruhn, Roberta L.

AU - Maskarinec, Gertraud

AU - Lopez, Ana Maria

AU - Wright, Nicole C.

AU - Moll, Carlos E.

AU - Aickin, Mikel

AU - Chen, Zhao

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N2 - OBJECTIVE: The extent to which modifiable dietary factors may account for some of the variability demonstrated in mammographic density across ethnic groups is unknown. The purpose of this study was to provide pilot data describing the relationship between dietary variables and mammographic density in pre- and postmenopausal Hispanic and non-Hispanic white (NHW) women (N = 238) ranging in age from 41 to 50 years (premenopausal only) or 56 to 70 years (postmenopausal only). DESIGN: Using a cross-sectional design, computer-assisted density assessments were performed on mammograms of both breasts and averaged for analysis. The Arizona Food Frequency Questionnaire was used to estimate dietary intake. RESULTS: Study participants were well educated and overweight, with mean mammographic densities ranging from 20.25% for postmenopausal Hispanic women to 46.94% for premenopausal NHW women. Hispanic women reported higher energy intake than NHW women, but energy-adjusted intake of other nutrients was generally comparable. There was preliminary evidence of ethnic variability in diet-mammographic density associations. Among premenopausal Hispanic women, density was inversely associated with dairy, calcium, and vitamin D intakes (P ≤ 0.05 for all). Among premenopausal NHW women, lower mammographic density was associated with greater intake of vegetables (P ≤ 0.05), and higher density was associated with greater fruit intake (P ≤ 0.05). Among postmenopausal Hispanic women, for every 4.54 increase in the polyunsaturated-to-saturated fat ratio, there was a 9.0% reduction in mammograph density. CONCLUSIONS: These preliminary results suggest that a differential pattern of dietary nutrient associations with mammographic density could potentially exist among Hispanic and NHW women. These ethnic differences in diet and mammographic density associations need to be further explored in larger studies.

AB - OBJECTIVE: The extent to which modifiable dietary factors may account for some of the variability demonstrated in mammographic density across ethnic groups is unknown. The purpose of this study was to provide pilot data describing the relationship between dietary variables and mammographic density in pre- and postmenopausal Hispanic and non-Hispanic white (NHW) women (N = 238) ranging in age from 41 to 50 years (premenopausal only) or 56 to 70 years (postmenopausal only). DESIGN: Using a cross-sectional design, computer-assisted density assessments were performed on mammograms of both breasts and averaged for analysis. The Arizona Food Frequency Questionnaire was used to estimate dietary intake. RESULTS: Study participants were well educated and overweight, with mean mammographic densities ranging from 20.25% for postmenopausal Hispanic women to 46.94% for premenopausal NHW women. Hispanic women reported higher energy intake than NHW women, but energy-adjusted intake of other nutrients was generally comparable. There was preliminary evidence of ethnic variability in diet-mammographic density associations. Among premenopausal Hispanic women, density was inversely associated with dairy, calcium, and vitamin D intakes (P ≤ 0.05 for all). Among premenopausal NHW women, lower mammographic density was associated with greater intake of vegetables (P ≤ 0.05), and higher density was associated with greater fruit intake (P ≤ 0.05). Among postmenopausal Hispanic women, for every 4.54 increase in the polyunsaturated-to-saturated fat ratio, there was a 9.0% reduction in mammograph density. CONCLUSIONS: These preliminary results suggest that a differential pattern of dietary nutrient associations with mammographic density could potentially exist among Hispanic and NHW women. These ethnic differences in diet and mammographic density associations need to be further explored in larger studies.

KW - Breast cancer

KW - Diet

KW - Mammographic density

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