Pilus expression in neisseria gonorrhoeae involves chromosomal rearrangement

Thomas F. Meyer, Natania Mlawer, Magdalene "Maggie" So

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

The Neisseria gonorrhoeae pilus protein is one of the major antigenic determinants on the cell's surface. It is comprised of identical subunits of approximately 18 kd and plays a role in the infectivity and virulence of the organism. We have cloned the gene encoding a gonococcal pilus protein into Escherichia coli, and, using one of these clones as a probe in hybridization studies, we have shown that conversion of the pilus positive to pilus negative state in N. gonorrhoeae involves chromosomal rearrangement. Although the pilus protein is produced by E. coli, it does not appear to be assembled on the surface of the cell in native form.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalCell
Volume30
Issue number1
DOIs
StatePublished - 1982
Externally publishedYes

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Neisseria gonorrhoeae
Escherichia coli
Escherichia coli Proteins
Virulence
Epitopes
Proteins
Gene encoding
Clone Cells
Genes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Pilus expression in neisseria gonorrhoeae involves chromosomal rearrangement. / Meyer, Thomas F.; Mlawer, Natania; So, Magdalene "Maggie".

In: Cell, Vol. 30, No. 1, 1982, p. 45-52.

Research output: Contribution to journalArticle

Meyer, Thomas F. ; Mlawer, Natania ; So, Magdalene "Maggie". / Pilus expression in neisseria gonorrhoeae involves chromosomal rearrangement. In: Cell. 1982 ; Vol. 30, No. 1. pp. 45-52.
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