Plant telomeres and telomerase

Andrew D.L. Nelson, Mark A Beilstein, Dorothy E. Shippen

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

The essential function of the telomere is to facilitate the complete replication of the chromosome terminus and to prevent the terminus from eliciting a DNA damage response that would cause genome instability. Telomere failure can occur from the loss of telomere capping proteins or the prolonged absence of telomerase. Because of its extraordinary tolerance to genome instability, Arabidopsis thaliana is a powerful model for telomere biology. Telomerase expression is highly regulated and in both plants and animals is confined to cells with long-term proliferation capacity. Unlike vertebrate telomeres, plant telomeres are asymmetric with one end of the chromosome terminating in a 30 single-stranded overhang and the other in a blunt end. The protein composition of plant telomeres reveals an evolutionary bridge with yeast and vertebrates; some factors are more like yeast, others more like vertebrates, and still others unique to plants. The identification and characterization of the CST complex in Arabidopsis paved the way for understanding the molecular basis of human stem cell disease. Gene duplication and diversification have had made a significant impact on the composition and regulation of Arabidopsis telomerase. The telomerase RNA component is evolving very rapidly in plants and is giving rise to novel regulatory mechanisms. De novo telomere formation by telomerase at internal double-strand breaks in the DNA causes loss of chromosomal DNA and must be strictly regulated to ensure faithful repair of DNA damage.

Original languageEnglish (US)
Title of host publicationMolecular Biology
PublisherSpringer New York
Pages25-49
Number of pages25
ISBN (Electronic)9781461475705
ISBN (Print)9781461475699
DOIs
StatePublished - Jan 1 2014

Fingerprint

Telomerase
Telomere
Arabidopsis
Vertebrates
Genomic Instability
DNA Damage
Chromosomes
Yeasts
Plant Proteins
Gene Duplication
Double-Stranded DNA Breaks
Stem Cells
DNA

ASJC Scopus subject areas

  • Psychology(all)

Cite this

Nelson, A. D. L., Beilstein, M. A., & Shippen, D. E. (2014). Plant telomeres and telomerase. In Molecular Biology (pp. 25-49). Springer New York. https://doi.org/10.1007/978-1-4614-7570-5_4

Plant telomeres and telomerase. / Nelson, Andrew D.L.; Beilstein, Mark A; Shippen, Dorothy E.

Molecular Biology. Springer New York, 2014. p. 25-49.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nelson, ADL, Beilstein, MA & Shippen, DE 2014, Plant telomeres and telomerase. in Molecular Biology. Springer New York, pp. 25-49. https://doi.org/10.1007/978-1-4614-7570-5_4
Nelson ADL, Beilstein MA, Shippen DE. Plant telomeres and telomerase. In Molecular Biology. Springer New York. 2014. p. 25-49 https://doi.org/10.1007/978-1-4614-7570-5_4
Nelson, Andrew D.L. ; Beilstein, Mark A ; Shippen, Dorothy E. / Plant telomeres and telomerase. Molecular Biology. Springer New York, 2014. pp. 25-49
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