Anticholinergische Plasmaaktivität und kognitive Funktion bei geriatrischen Patienten.

Translated title of the contribution: Plasma anticholinergic activity and cognitive function in geriatric patients

O. J. Thienhaus, J. Thoene, A. Allen, F. P. Zemlan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

This study evaluated the putative impact of circulating anticholinergic equivalents on cognitive functional performance in non-demented geropsychiatric inpatients. Standard rating instruments were administered to measure memory functions, concentration and overall functional competency. Anticholinergic plasma activity was assayed, using a radioreceptor technique with tritiated quinuclidinyl benzilate as the active reagent. None of the cognitive tests employed indicated a statistically significant change in the subjects' quantifiable level of cognitive performance. All changes in anticholinergic activities were related to adjustments in psychotherapeutic medications. The possible role of reversal of pseudodementing features is discussed as well as the potential for monitoring anticholinergic activity when treating elderly individuals with more than one centrally active medication having anticholinergic properties.

Translated title of the contributionPlasma anticholinergic activity and cognitive function in geriatric patients
Original languageGerman
Pages (from-to)275-281
Number of pages7
JournalPsychiatrie Neurologie und Medizinische Psychologie
Volume42
Issue number5
StatePublished - May 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Neurology

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