Plasma beta-endorphin concentrations and analgesia-muscle relaxation in the newborn infant supported by mechanical ventilation

Stavros P. Ionides, Marc G. Weiss, Margarite Angelopoulos, Thomas F. Myers, Robert J. Handa

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

We evaluated the effects of pancuronium and opiates on plasma β-endorphin concentrations in 25 infants supported by mechanical ventilation. Infants receiving opiate were randomly assigned to receive either fentanyl or morphine. There was no change in β-endorphin concentrations after administration of pancuronium, whereas both fentanyl and morphine reduced β-endorphin concentrations by approximately 60%. (J PEDIATR 1994;125:113-6)

Original languageEnglish (US)
Pages (from-to)113-116
Number of pages4
JournalJournal of Pediatrics
Volume125
Issue number1
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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