Plasma beta-endorphin concentrations and analgesia-muscle relaxation in the newborn infant supported by mechanical ventilation

S. P. Ionides, M. G. Weiss, M. Angelopoulos, T. F. Myers, Robert J Handa

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We evaluated the effects of pancuronium and opiates on plasma β-endorphin concentrations in 25 infants supported by mechanical ventilation. Infants receiving opiate were randomly assigned to receive either fentanyl or morphine. There was no change in β-endorphin concentrations after administration of pancuronium, whereas both fentanyl and morphine reduced β-endorphin concentrations by approximately 60%.

Original languageEnglish (US)
Pages (from-to)113-116
Number of pages4
JournalThe Journal of Pediatrics
Volume125
Issue number1
DOIs
StatePublished - 1994
Externally publishedYes

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Endorphins
Muscle Relaxation
beta-Endorphin
Opiate Alkaloids
Artificial Respiration
Analgesia
Pancuronium
Newborn Infant
Fentanyl
Morphine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Plasma beta-endorphin concentrations and analgesia-muscle relaxation in the newborn infant supported by mechanical ventilation. / Ionides, S. P.; Weiss, M. G.; Angelopoulos, M.; Myers, T. F.; Handa, Robert J.

In: The Journal of Pediatrics, Vol. 125, No. 1, 1994, p. 113-116.

Research output: Contribution to journalArticle

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