Plasma folate, vitamin B6, Vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts

Eva Schernhammer, Brian Wolpin, Nader Rifai, Barbara Cochrane, Jo Ann Manson, Jing Ma, Ed Giovannucci, Cynthia Thomson, Meir J. Stampfer, Charles Fuchs

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Abstract

Folate deficiency induces DNA breaks and may alter cellular capacity for mutation and epigenetic methylation. Few studies have examined the influence of one-carbon nutrients on pancreatic cancer risk, although recent studies suggest a potential protective effect for one-carbon nutrients from food sources, but not from supplements. We conducted a prospective nested case-control study to examine plasma concentrations of folate, vitamin B6 [whose main circulating form is pyridoxal-5′-phosphate (PLP)], vitamin B12, and homocysteine in relationship to pancreatic cancer, using four large prospective cohorts. Multivariable adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using conditional logistic regression. All statistical tests were two sided. Among 208 cases and 623 controls, we observed no association between folate, PLP, vitamin B12, or homocysteine and pancreatic cancer risk. Comparing the highest to lowest quartiles of plasma concentration, the ORs were 1.20 (95% CI, 0.76-1.91) for folate, 0.80 (95% CI, 0.51-1.25) for B6, 0.91 (95% CI, 0.57-1.46) for B12, and 1.43 (95% CI, 0.90-2.28) for homocysteine. In analyses restricted to nonusers of multivitamins, we observe a modest inverse trend between folate, PLP, and B12 and pancreatic cancer risk. In contrast, no such inverse associations were observed among study subjects who reported multivitamin supplement use. Among all participants, plasma levels of folate, B6, B12, and homocysteine were not associated with a significant reduction in the risk of pancreatic cancer. Among participants who obtain these factors exclusively through dietary sources, there may be an inverse relation between circulating folate, B6, and B12 and risk.

Original languageEnglish (US)
Pages (from-to)5553-5560
Number of pages8
JournalCancer Research
Volume67
Issue number11
DOIs
StatePublished - Jun 1 2007

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Vitamin B 6
Homocysteine
Vitamin B 12
Pancreatic Neoplasms
Folic Acid
Pyridoxal Phosphate
Confidence Intervals
Food
Carbon
DNA Breaks
Risk Reduction Behavior
Epigenomics
Methylation
Case-Control Studies
Logistic Models
Odds Ratio
Mutation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Schernhammer, E., Wolpin, B., Rifai, N., Cochrane, B., Manson, J. A., Ma, J., ... Fuchs, C. (2007). Plasma folate, vitamin B6, Vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts. Cancer Research, 67(11), 5553-5560. https://doi.org/10.1158/0008-5472.CAN-06-4463

Plasma folate, vitamin B6, Vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts. / Schernhammer, Eva; Wolpin, Brian; Rifai, Nader; Cochrane, Barbara; Manson, Jo Ann; Ma, Jing; Giovannucci, Ed; Thomson, Cynthia; Stampfer, Meir J.; Fuchs, Charles.

In: Cancer Research, Vol. 67, No. 11, 01.06.2007, p. 5553-5560.

Research output: Contribution to journalArticle

Schernhammer, E, Wolpin, B, Rifai, N, Cochrane, B, Manson, JA, Ma, J, Giovannucci, E, Thomson, C, Stampfer, MJ & Fuchs, C 2007, 'Plasma folate, vitamin B6, Vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts', Cancer Research, vol. 67, no. 11, pp. 5553-5560. https://doi.org/10.1158/0008-5472.CAN-06-4463
Schernhammer, Eva ; Wolpin, Brian ; Rifai, Nader ; Cochrane, Barbara ; Manson, Jo Ann ; Ma, Jing ; Giovannucci, Ed ; Thomson, Cynthia ; Stampfer, Meir J. ; Fuchs, Charles. / Plasma folate, vitamin B6, Vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts. In: Cancer Research. 2007 ; Vol. 67, No. 11. pp. 5553-5560.
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abstract = "Folate deficiency induces DNA breaks and may alter cellular capacity for mutation and epigenetic methylation. Few studies have examined the influence of one-carbon nutrients on pancreatic cancer risk, although recent studies suggest a potential protective effect for one-carbon nutrients from food sources, but not from supplements. We conducted a prospective nested case-control study to examine plasma concentrations of folate, vitamin B6 [whose main circulating form is pyridoxal-5′-phosphate (PLP)], vitamin B12, and homocysteine in relationship to pancreatic cancer, using four large prospective cohorts. Multivariable adjusted odds ratios (OR) and 95{\%} confidence intervals (95{\%} CI) were calculated using conditional logistic regression. All statistical tests were two sided. Among 208 cases and 623 controls, we observed no association between folate, PLP, vitamin B12, or homocysteine and pancreatic cancer risk. Comparing the highest to lowest quartiles of plasma concentration, the ORs were 1.20 (95{\%} CI, 0.76-1.91) for folate, 0.80 (95{\%} CI, 0.51-1.25) for B6, 0.91 (95{\%} CI, 0.57-1.46) for B12, and 1.43 (95{\%} CI, 0.90-2.28) for homocysteine. In analyses restricted to nonusers of multivitamins, we observe a modest inverse trend between folate, PLP, and B12 and pancreatic cancer risk. In contrast, no such inverse associations were observed among study subjects who reported multivitamin supplement use. Among all participants, plasma levels of folate, B6, B12, and homocysteine were not associated with a significant reduction in the risk of pancreatic cancer. Among participants who obtain these factors exclusively through dietary sources, there may be an inverse relation between circulating folate, B6, and B12 and risk.",
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