Plasma norepinephrine responses of man in cold water

David G Johnson, J. S. Hayward, T. P. Jacobs, M. L. Collis, J. D. Eckerson, R. H. Williams

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

The hypothermic stress of immersion in cold water stimulates release of norepinephrine from the sympathetic nervous system. The speed and pattern of this response was studied in six healthy men by serial measurements of plasma norepinephrine concentrations before, during, and after 60 min of immersion in 10°C water. After immersion for 2 min, the mean norepinephrine concentration was increased from 359 ± 32 (basal) to 642 ± 138 pg/ml and rose gradually to a maximum of 1,171 ± 226 pg/ml after 45 min of immersion. Metabolic rate increased approximately threefold during the immersion period. After rewarming in warm water (40°C), the subjects showed a transient peak in plasma norepinephrine followed by a rapid decrease to basal levels after 30 min. The fall in plasma norepinephrine after approximately 8 min of rewarming occurred despite persistent depression of the core temperature and coincided with a sudden decrease in metabolic rate and cessation of body shivering. These results suggest that the sympathetic nervous response to cold can be activated or suppressed very quickly and is dependent on the skin temperature.

Original languageEnglish (US)
Pages (from-to)216-220
Number of pages5
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume43
Issue number2
StatePublished - 1977
Externally publishedYes

Fingerprint

Immersion
Norepinephrine
Water
Rewarming
Shivering
Skin Temperature
Sympathetic Nervous System
Temperature

ASJC Scopus subject areas

  • Physiology
  • Endocrinology

Cite this

Johnson, D. G., Hayward, J. S., Jacobs, T. P., Collis, M. L., Eckerson, J. D., & Williams, R. H. (1977). Plasma norepinephrine responses of man in cold water. Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, 43(2), 216-220.

Plasma norepinephrine responses of man in cold water. / Johnson, David G; Hayward, J. S.; Jacobs, T. P.; Collis, M. L.; Eckerson, J. D.; Williams, R. H.

In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 43, No. 2, 1977, p. 216-220.

Research output: Contribution to journalArticle

Johnson, DG, Hayward, JS, Jacobs, TP, Collis, ML, Eckerson, JD & Williams, RH 1977, 'Plasma norepinephrine responses of man in cold water', Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, vol. 43, no. 2, pp. 216-220.
Johnson, David G ; Hayward, J. S. ; Jacobs, T. P. ; Collis, M. L. ; Eckerson, J. D. ; Williams, R. H. / Plasma norepinephrine responses of man in cold water. In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 1977 ; Vol. 43, No. 2. pp. 216-220.
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