Plasmid-DNA lipid nanovaccines: An innovative approach for a better world health

Aurora García-Rendón, Adriana Garibay-Escobar, Roberto Guzmán, Armando Tejeda-Mansir

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

One of the most important applications of immunology has been the production of various types of vaccines. Currently, new plasmid DNA (pDNA) vaccines are been developed, given rise to more cost-effective and clean production processes. These processes involve the upstream and downstream stages to produce, isolate, and purify the pDNA. The effectiveness of pDNA vaccines against pathogen microorganisms and cancer cells has been demonstrated in clinical assays and in commercial veterinary vaccines. However, low transfection efficiency and brief transgene expression have been attained in some trials. The use of cationic lipid-based nanoparticles to avoid these problems is an alternative approach that has been tested clinically. This chapter provides a summary of the advances and major challenges associated with the fusion of pDNA production technology and nanoparticle delivery technologies to produce pDNA lipid nanovaccines.

Original languageEnglish (US)
Title of host publicationLipid Nanocarriers for Drug Targeting
PublisherElsevier
Pages231-267
Number of pages37
ISBN (Electronic)9780128136874
ISBN (Print)9780128136881
DOIs
StatePublished - Jan 1 2018

Keywords

  • Bioprocesses
  • Liposomes
  • Nanoparticles
  • Nanovaccines
  • Plasmid DNA
  • Vaccines

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)

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