Plasmon resonant liposomes for controlled drug delivery

Shellie S. Knights-Mitchell, Marek Romanowski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nanotechnology use in drug delivery promotes a reduction in systemic toxicity, improved pharmacokinetics, and better drug bioavailability. Liposomes continue to be extensively researched as drug delivery systems (DDS) with formulations such as Doxil® and Ambisome® approved by FDA and successfully marketed in the United States. However, the limited ability to precisely control release of active ingredients from these vesicles continues to challenge the broad implementation of this technology. Moreover, the full potential of the carrier to sequester drugs until it can reach its intended target has yet to be realized. Here, we describe a liposomal DDS that releases therapeutic doses of an anticancer drug in response to external stimulus. Earlier, we introduced degradable plasmon resonant liposomes. These constructs, obtained by reducing gold on the liposome surface, facilitate spatial and temporal release of drugs upon laser light illumination that ultimately induces an increase in temperature. In this work, plasmon resonant liposomes have been developed to stably encapsulate and retain doxorubicin at physiological conditions represented by isotonic saline at 37 °C and pH 7.4. Subsequently, they are stimulated to release contents either by a 5 °C increase in temperature or by laser illumination (760 nm and 88 mW/cm2 power density). Successful development of degradable plasmon resonant liposomes responsive to near-infrared light or moderate hyperthermia can provide a new delivery method for multiple lipophilic and hydrophilic drugs with pharmacokinetic profiles that limit clinical utility.

Original languageEnglish (US)
Title of host publicationColloidal Nanoparticles for Biomedical Applications X
EditorsWolfgang J. Parak, Marek Osinski, Xing-Jie Liang
PublisherSPIE
ISBN (Electronic)9781628414288
DOIs
StatePublished - Jan 1 2015
EventColloidal Nanoparticles for Biomedical Applications X - San Francisco, United States
Duration: Feb 7 2015Feb 9 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9338
ISSN (Print)1605-7422

Other

OtherColloidal Nanoparticles for Biomedical Applications X
CountryUnited States
CitySan Francisco
Period2/7/152/9/15

Keywords

  • Liposomes
  • drug delivery
  • nanomedicine
  • plasmon resonance

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Knights-Mitchell, S. S., & Romanowski, M. (2015). Plasmon resonant liposomes for controlled drug delivery. In W. J. Parak, M. Osinski, & X-J. Liang (Eds.), Colloidal Nanoparticles for Biomedical Applications X [93381D] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9338). SPIE. https://doi.org/10.1117/12.2080485