Plasticity of binocularity and visual acuity are differentially limited by nogo receptor

Céleste Élise Stephany, Leanne L H Chan, Sherveen N. Parivash, Hilary M. Dorton, Mariel Piechowicz, Shenfeng Qiu, Aaron W. McGee

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The closure of developmental critical periods consolidates neural circuitry but also limits recovery from early abnormal sensory experience. Degrading vision by one eye throughout a critical period both perturbs ocular dominance (OD) in primary visual cortex and impairs visual acuity permanently. Yet understanding how binocularity and visual acuity interrelate has proven elusive. Here we demonstrate the plasticity of binocularity and acuity are separable and differentially regulated by the neuronal nogo receptor 1 (NgR1). Mice lacking NgR1 display developmental OD plasticity as adults and their visual acuity spontaneously improves after prolonged monocular deprivation. Restricting deletion of NgR1 to either cortical interneurons or a subclass of parvalbumin (PV)-positive interneurons alters intralaminar synaptic connectivity in visual cortex and prevents closure of the critical period for OD plasticity. However, loss of NgR1 in PV neurons does not rescue deficits in acuity induced by chronic visual deprivation. Thus, NgR1 functions with PV interneurons to limit plasticity of binocularity, but its expression is required more extensively within brain circuitry to limit improvement of visual acuity following chronic deprivation.

Original languageEnglish (US)
Pages (from-to)11631-11640
Number of pages10
JournalJournal of Neuroscience
Volume34
Issue number35
DOIs
StatePublished - Aug 27 2014

Fingerprint

Visual Acuity
ocular Dominance
Parvalbumins
Interneurons
Visual Cortex
Nogo Receptor 1
Nogo Receptors
Neurons
Brain
Critical Period (Psychology)

Keywords

  • Cre recombinase
  • Mice
  • Nogo receptor
  • Ocular dominance plasticity
  • Parvalbumin
  • Visual acuity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Stephany, C. É., Chan, L. L. H., Parivash, S. N., Dorton, H. M., Piechowicz, M., Qiu, S., & McGee, A. W. (2014). Plasticity of binocularity and visual acuity are differentially limited by nogo receptor. Journal of Neuroscience, 34(35), 11631-11640. https://doi.org/10.1523/JNEUROSCI.0545-14.2014

Plasticity of binocularity and visual acuity are differentially limited by nogo receptor. / Stephany, Céleste Élise; Chan, Leanne L H; Parivash, Sherveen N.; Dorton, Hilary M.; Piechowicz, Mariel; Qiu, Shenfeng; McGee, Aaron W.

In: Journal of Neuroscience, Vol. 34, No. 35, 27.08.2014, p. 11631-11640.

Research output: Contribution to journalArticle

Stephany, CÉ, Chan, LLH, Parivash, SN, Dorton, HM, Piechowicz, M, Qiu, S & McGee, AW 2014, 'Plasticity of binocularity and visual acuity are differentially limited by nogo receptor', Journal of Neuroscience, vol. 34, no. 35, pp. 11631-11640. https://doi.org/10.1523/JNEUROSCI.0545-14.2014
Stephany, Céleste Élise ; Chan, Leanne L H ; Parivash, Sherveen N. ; Dorton, Hilary M. ; Piechowicz, Mariel ; Qiu, Shenfeng ; McGee, Aaron W. / Plasticity of binocularity and visual acuity are differentially limited by nogo receptor. In: Journal of Neuroscience. 2014 ; Vol. 34, No. 35. pp. 11631-11640.
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