Platelet-mediated thrombolysis in patients with δ-storage pool deficiency: A thrombelastographic analysis

Melissa A. Brodsky, Kelly A. MacHovec, Bryan P. Chambers, Vance G Nielsen

Research output: Contribution to journalArticle

Abstract

We present the first thrombelastographic descriptions of three patients with δ-storage pool deficiency, a platelet disorder that involves a deficiency of dense granules and moderate bleeding. The patients demonstrated a 49-54% loss of platelet-mediated clot strength over a 1-2-h period after normal thrombus formation. This pattern persisted, with some attenuation of loss of strength following administration of epsilon aminocaproic acid, desmopressin and platelets for tonsillectomy. Assessment of platelet function in patients with platelet granule disorders can be accomplished with thrombelastographic methods in ambulatory and perioperative settings; however, the effects of therapy for this disorder cannot be monitored with thrombelastography without obtaining a blood sample prior to prophylactic hemostatic intervention.

Original languageEnglish (US)
Pages (from-to)610-612
Number of pages3
JournalBlood Coagulation and Fibrinolysis
Volume22
Issue number7
DOIs
StatePublished - Oct 2011
Externally publishedYes

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Platelet Storage Pool Deficiency
Blood Platelets
Thrombelastography
Aminocaproic Acid
Deamino Arginine Vasopressin
Tonsillectomy
Hemostatics
Thrombosis
Hemorrhage

Keywords

  • δ-storage pool deficiency
  • platelet granule disorder
  • thrombelastography

ASJC Scopus subject areas

  • Hematology

Cite this

Platelet-mediated thrombolysis in patients with δ-storage pool deficiency : A thrombelastographic analysis. / Brodsky, Melissa A.; MacHovec, Kelly A.; Chambers, Bryan P.; Nielsen, Vance G.

In: Blood Coagulation and Fibrinolysis, Vol. 22, No. 7, 10.2011, p. 610-612.

Research output: Contribution to journalArticle

Brodsky, Melissa A. ; MacHovec, Kelly A. ; Chambers, Bryan P. ; Nielsen, Vance G. / Platelet-mediated thrombolysis in patients with δ-storage pool deficiency : A thrombelastographic analysis. In: Blood Coagulation and Fibrinolysis. 2011 ; Vol. 22, No. 7. pp. 610-612.
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