Platelet-rich plasma, bilayered acellular matrix grafting and negative pressure wound therapy in diabetic foot infection

W. Deng, J. Boey, B. Chen, S. Byun, E. Lew, Z. Liang, David G Armstrong

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Management and treatment of acute severe diabetic foot disease in patients with suboptimal glycaemic control is a critical issue in wound repair. This paper discusses the clinical efficacy of an aggressive surgical intervention combined with targeted use of regenerative medical therapies in limb preservation. Negative pressure wound therapy (NPWT), platelet-rich plasma (PRP), bilayered acellular matrix grafting and split-thickness skin grafting were combined to treat a patient with diabetes, foot necrotising fasciitis and gaseous gangrene. The wound was completely healed. The clinical outcome revealed that a multi-intervention strategy could be effective for large necrotising fasciitis wounds. Early clinical observation, suggests aggresive surgical intervention preserving intact tissue and targeted use of new regenerative technologies can lead to preservation of a limb.

Original languageEnglish (US)
Pages (from-to)393-397
Number of pages5
JournalJournal of wound care
Volume25
Issue number7
DOIs
StatePublished - Jul 1 2016

Keywords

  • Bilayered acellular matrix grafting
  • Diabetic foot
  • Negative pressure wound therapy
  • Platelet-rich plasma
  • Wound healing

ASJC Scopus subject areas

  • Fundamentals and skills
  • Nursing (miscellaneous)

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