Pneumococcus‐specific immunoglobulin E in cigarette smokers

John W Bloom, MARILYN HALONEN, ANITA M. DUNN, J. L. PINNAS, B. BURROWS

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A relationship between elevated scrum immunoglobulin E levels and smoking has been demonstrated in epidemiological studies. Allergy skin test data suggest that the excess immunoglobulin E of smokers is not specific for aeroallergens. It is possible that the excess immunoglobulin E is specific for microorganisms that often infect the lower respiratory tract of smokers. To investigate this possibility we utilized a radio‐allergosorbent test assay for detecting serum immunoglobulin E specific for Streptococcus pneumoniae, an organism commonly isolated from the respiratory tract of smokers with chronic bronchitis. We assayed sera of thirty smokers and thirty nonsmokers for immunoglobulin E specific for Streptococcus pneumoniae. Individual sera were considered positive for pneumococcus‐specific immunoglobulin E if the binding was at least twice the non‐specific binding at the total immunoglobulin E concentration of the particular serum. Eleven of the thirty sera of smokers and two of the thirty nonsmokers were positive for pneumococcus‐specific immunoglobulin E. By chi‐square analysis of these data, the prevalence of pneumococcus‐specific immunoglobulin E was significantly greater in the smoking group compared with the non‐smoking group (P<0·02). These results suggest that the excess immunoglobulin E of smokers is, at least in part, specific for microorganisms that infect the airways.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalClinical & Experimental Allergy
Volume16
Issue number1
DOIs
StatePublished - 1986

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Immunoglobulin E
Serum
Streptococcus pneumoniae
Respiratory System
Smoking
Electronic Cigarettes
Radioallergosorbent Test
Chronic Bronchitis
Skin Tests
Epidemiologic Studies
Hypersensitivity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Pneumococcus‐specific immunoglobulin E in cigarette smokers. / Bloom, John W; HALONEN, MARILYN; DUNN, ANITA M.; PINNAS, J. L.; BURROWS, B.

In: Clinical & Experimental Allergy, Vol. 16, No. 1, 1986, p. 25-32.

Research output: Contribution to journalArticle

Bloom, John W ; HALONEN, MARILYN ; DUNN, ANITA M. ; PINNAS, J. L. ; BURROWS, B. / Pneumococcus‐specific immunoglobulin E in cigarette smokers. In: Clinical & Experimental Allergy. 1986 ; Vol. 16, No. 1. pp. 25-32.
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