Pneumocystis carinii Pneumonia associated with profound lymphopenia and abnormal T-lymphocyte subset ratios during treatment for early-stage breast cancer

M. W. Brunvand, C. Collins, Robert B Livingston, G. Raghu

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Two women with Stage II breast carcinoma treated with lumpectomy followed by breast irradiation and adjuvant chemotherapy developed Pneumecystis carinii pneumonia while receiving cytotoxic chemotherapy. Neither woman had evidence of immunosuppression before therapy. They both had profound lymphopenia, reversed CD4/CD8 ratios, and normal peripheral blood total leukocyte counts at the time of their infections. Both women were seronegative for human immunodeficiency virus type 1 and had no risk factors for such an infection. The patients' CD4 lymphocyte counts increased after chemotherapy for breast carcinoma was discontinued. Thus, it appears that the therapy they received may have caused severe T-lymphocyte mediated immunosuppression.

Original languageEnglish (US)
Pages (from-to)2407-2409
Number of pages3
JournalCancer
Volume67
Issue number9
StatePublished - 1991
Externally publishedYes

Fingerprint

Lymphopenia
Pneumocystis Pneumonia
T-Lymphocyte Subsets
Breast Neoplasms
Immunosuppression
Drug Therapy
CD4-CD8 Ratio
Segmental Mastectomy
Adjuvant Chemotherapy
CD4 Lymphocyte Count
Infection
Leukocyte Count
HIV-1
Pneumonia
Breast
Therapeutics
T-Lymphocytes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pneumocystis carinii Pneumonia associated with profound lymphopenia and abnormal T-lymphocyte subset ratios during treatment for early-stage breast cancer. / Brunvand, M. W.; Collins, C.; Livingston, Robert B; Raghu, G.

In: Cancer, Vol. 67, No. 9, 1991, p. 2407-2409.

Research output: Contribution to journalArticle

@article{8eea1a8d0fbd4f09abd28d24b3a3107e,
title = "Pneumocystis carinii Pneumonia associated with profound lymphopenia and abnormal T-lymphocyte subset ratios during treatment for early-stage breast cancer",
abstract = "Two women with Stage II breast carcinoma treated with lumpectomy followed by breast irradiation and adjuvant chemotherapy developed Pneumecystis carinii pneumonia while receiving cytotoxic chemotherapy. Neither woman had evidence of immunosuppression before therapy. They both had profound lymphopenia, reversed CD4/CD8 ratios, and normal peripheral blood total leukocyte counts at the time of their infections. Both women were seronegative for human immunodeficiency virus type 1 and had no risk factors for such an infection. The patients' CD4 lymphocyte counts increased after chemotherapy for breast carcinoma was discontinued. Thus, it appears that the therapy they received may have caused severe T-lymphocyte mediated immunosuppression.",
author = "Brunvand, {M. W.} and C. Collins and Livingston, {Robert B} and G. Raghu",
year = "1991",
language = "English (US)",
volume = "67",
pages = "2407--2409",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

TY - JOUR

T1 - Pneumocystis carinii Pneumonia associated with profound lymphopenia and abnormal T-lymphocyte subset ratios during treatment for early-stage breast cancer

AU - Brunvand, M. W.

AU - Collins, C.

AU - Livingston, Robert B

AU - Raghu, G.

PY - 1991

Y1 - 1991

N2 - Two women with Stage II breast carcinoma treated with lumpectomy followed by breast irradiation and adjuvant chemotherapy developed Pneumecystis carinii pneumonia while receiving cytotoxic chemotherapy. Neither woman had evidence of immunosuppression before therapy. They both had profound lymphopenia, reversed CD4/CD8 ratios, and normal peripheral blood total leukocyte counts at the time of their infections. Both women were seronegative for human immunodeficiency virus type 1 and had no risk factors for such an infection. The patients' CD4 lymphocyte counts increased after chemotherapy for breast carcinoma was discontinued. Thus, it appears that the therapy they received may have caused severe T-lymphocyte mediated immunosuppression.

AB - Two women with Stage II breast carcinoma treated with lumpectomy followed by breast irradiation and adjuvant chemotherapy developed Pneumecystis carinii pneumonia while receiving cytotoxic chemotherapy. Neither woman had evidence of immunosuppression before therapy. They both had profound lymphopenia, reversed CD4/CD8 ratios, and normal peripheral blood total leukocyte counts at the time of their infections. Both women were seronegative for human immunodeficiency virus type 1 and had no risk factors for such an infection. The patients' CD4 lymphocyte counts increased after chemotherapy for breast carcinoma was discontinued. Thus, it appears that the therapy they received may have caused severe T-lymphocyte mediated immunosuppression.

UR - http://www.scopus.com/inward/record.url?scp=0026332521&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026332521&partnerID=8YFLogxK

M3 - Article

C2 - 2013044

AN - SCOPUS:0026332521

VL - 67

SP - 2407

EP - 2409

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 9

ER -