Point-of-care, smartphone-based, dual-modality, dual-view, oral cancer screening device with neural network classification for low-resource communities

Ross D. Uthoff, Bofan Song, Sumsum Sunny, Sanjana Patrick, Amritha Suresh, Trupti Kolur, G. Keerthi, Oliver Spires, Afarin Anbarani, Petra Wilder-Smith, Moni Abraham Kuriakose, Praveen Birur, Rongguang Liang

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Oral cancer is a growing health issue in a number of low- and middle-income countries (LMIC), particularly in South and Southeast Asia. The described dual-modality, dual-view, point-of-care oral cancer screening device, developed for high-risk populations in remote regions with limited infrastructure, implements autofluorescence imaging (AFI) and white light imaging (WLI) on a smartphone platform, enabling early detection of pre-cancerous and cancerous lesions in the oral cavity with the potential to reduce morbidity, mortality, and overall healthcare costs. Using a custom Android application, this device synchronizes external light-emitting diode (LED) illumination and image capture for AFI and WLI. Data is uploaded to a cloud server for diagnosis by a remote specialist through a web app, with the ability to transmit triage instructions back to the device and patient. Finally, with the on-site specialist’s diagnosis as the gold-standard, the remote specialist and a convolutional neural network (CNN) were able to classify 170 image pairs into ‘suspicious’ and ‘not suspicious’ with sensitivities, specificities, positive predictive values, and negative predictive values ranging from 81.25% to 94.94%.

Original languageEnglish (US)
Article numbere0207493
JournalPLoS One
Volume13
Issue number12
DOIs
StatePublished - Dec 1 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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    Uthoff, R. D., Song, B., Sunny, S., Patrick, S., Suresh, A., Kolur, T., Keerthi, G., Spires, O., Anbarani, A., Wilder-Smith, P., Kuriakose, M. A., Birur, P., & Liang, R. (2018). Point-of-care, smartphone-based, dual-modality, dual-view, oral cancer screening device with neural network classification for low-resource communities. PLoS One, 13(12), [e0207493]. https://doi.org/10.1371/journal.pone.0207493