Polarity in skeletal muscle cells is induced by innervation

Steven J. Burden, Sangmee Ahn Jo, Jichen Tang, Xuejun Zhu, James E. Yeadon, Alexander M. Simon

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Skeletal muscle fibers are specialized at the site of the neuromuscular synapse, and this polarity is acquired during development and maintained in the adult as a consequence of inductive interactions between nerve and muscle. This review summarizes recent experiments which demonstrate that two different signalling pathways, a transcriptional pathway and a post-translational pathway, have an important role in the formation and maintenance of the neuromuscular synapse and mediate the induction of polarity in skeletal muscle fibers.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalSeminars in Developmental Biology
Volume6
Issue number1
DOIs
StatePublished - Feb 1995
Externally publishedYes

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Keywords

  • acetylcholine receptors
  • agrin
  • dystroglycan
  • erbB
  • neuregulin

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