Poly(A) shortening of coregulated transcripts in Drosophila

Linda L Restifo, Gregory M. Guild

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The 71E ecdysterone-regulated puff of Drosophila melanogaster contains a cluster of six coregulated "late" genes which are expressed in the prepupal salivary gland. The resulting transcripts exhibit a decrease in their length during the 12-hr period in which they accumulate. Using the enzyme ribonuclease H, we show that this size decrease is a result of a progressively shorter poly(A) tract and suggest that these transcripts undergo an active sequential shortening of their poly(A) tracts in prepupal salivary glands. It is interesting to note that this shortening precedes the complete loss of these transcripts from the RNA population.

Original languageEnglish (US)
Pages (from-to)507-510
Number of pages4
JournalDevelopmental Biology
Volume115
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Poly A
Salivary Glands
Drosophila
Ecdysterone
Ribonuclease H
Drosophila melanogaster
RNA
Enzymes
Population
Genes

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Poly(A) shortening of coregulated transcripts in Drosophila. / Restifo, Linda L; Guild, Gregory M.

In: Developmental Biology, Vol. 115, No. 2, 1986, p. 507-510.

Research output: Contribution to journalArticle

Restifo, Linda L ; Guild, Gregory M. / Poly(A) shortening of coregulated transcripts in Drosophila. In: Developmental Biology. 1986 ; Vol. 115, No. 2. pp. 507-510.
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